Expectations
- Organism
- Homo sapiens
- Assay
- bulk RNA-seq
- Specimen/source
- patient tissue or biopsy
- Controls
- matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control
Siftome Phase 3L
GSE107502Both case and control groups are present in the proposed grouping.
Each contrast group has at least 2 samples.
Processed data is marked available in the GEO index.
All samples are assigned to a case or control group.
No dataset warnings are present.
Metadata quality is high enough to support downstream handoff.
No readiness blockers detected.
Siftome proposed case and control labels, but no reviewer confirmation is stored yet.
Open the sample grouping CSV and confirm group labels before analysis.Both groups meet the minimum of 2 samples.
Confirm whether the cohort is large enough for the intended statistical analysis.Processed data availability is marked true in the GEO index.
Verify that downloaded processed files contain usable count or expression identifiers.No review-needed or unassigned samples are present in the proposed grouping.
Still scan the grouping table for biology-specific ambiguity.No hard-excluded samples were detected by the current rules.
Record any manual exclusions in the downstream analysis notes.The dataset and sample accessions can be linked back to GEO.
Keep GEO dataset and sample links with exported metadata.Proceed only after the analyst confirms grouping, exclusions, and source files.
No expert-review triggers were detected by Siftome.
No ranking warnings are active.
No active review decisions affect this ranking.
No active manual corrections are applied to this dataset.
Homo sapiens
dataset_accession: GSE107502 organism: Homo sapiens dataset_title: Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 (RNA-Seq)
bulk RNA-seq
assay_type: bulk RNA-seq experiment_types: Expression profiling by high throughput sequencing platforms: GPL11154 Illumina HiSeq 2000 (Homo sapiens) dataset_title: Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 (RNA-Seq)
Tumor vs unmatched normal
dataset_title: Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 (RNA-Seq) experiment_types: Expression profiling by high throughput sequencing sample_context: GSM2869456: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 6; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low GSM2869457: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 6; protocol: post-treatment surgical resection; tumor sample subtype: claudin low GSM2869458: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal GSM2869459: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal GSM28694 [Correction source preview truncated.]
Biopsy
dataset_title: Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 (RNA-Seq) sample_context: GSM2869456: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 6; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low GSM2869457: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 6; protocol: post-treatment surgical resection; tumor sample subtype: claudin low GSM2869458: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal GSM2869459: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal GSM2869460: source_name=breast carcinoma; characteristics=disease state: TNBC [Correction source preview truncated.]
breast cancer
dataset_title: Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 (RNA-Seq) sample_context: GSM2869456: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 6; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low GSM2869457: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 6; protocol: post-treatment surgical resection; tumor sample subtype: claudin low GSM2869458: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal GSM2869459: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal GSM2869460: source_name=breast carcinoma; characteristics=disease state: TNBC [Correction source preview truncated.]
Eligible for Patient tissue tumor-vs-normal as Not suitable
dataset_accession: GSE107502 dataset_title: Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 (RNA-Seq) organism: Homo sapiens assay_type: bulk RNA-seq sample_context: GSM2869456: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 6; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low GSM2869457: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 6; protocol: post-treatment surgical resection; tumor sample subtype: claudin low GSM2869458: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal GSM2869459: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal [Correction source preview truncated.]
Eligible for Patient tissue tumor-vs-normal as Not suitable
dataset_accession: GSE107502 dataset_title: Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 (RNA-Seq) organism: Homo sapiens assay_type: bulk RNA-seq sample_context: GSM2869456: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 6; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low GSM2869457: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 6; protocol: post-treatment surgical resection; tumor sample subtype: claudin low GSM2869458: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal GSM2869459: source_name=breast carcinoma; characteristics=disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal [Correction source preview truncated.]
tumor sample (case)
sample_accession: GSM2869456 sample_title: Patient 6 needle core biospy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 6; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low
Included in derived sample grouping as tumor sample
sample_accession: GSM2869456 sample_title: Patient 6 needle core biospy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 6; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low
tumor sample (case)
sample_accession: GSM2869457 sample_title: Patient 6 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 6; protocol: post-treatment surgical resection; tumor sample subtype: claudin low
Included in derived sample grouping as tumor sample
sample_accession: GSM2869457 sample_title: Patient 6 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 6; protocol: post-treatment surgical resection; tumor sample subtype: claudin low
tumor sample (case)
sample_accession: GSM2869458 sample_title: Patient 5 needle core biopsy - pre treatment_2 source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869458 sample_title: Patient 5 needle core biopsy - pre treatment_2 source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869459 sample_title: Patient 5 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869459 sample_title: Patient 5 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 5; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869460 sample_title: Patient 5 surgical resection - post treatment_2 source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 5; protocol: post-treatment surgical resection; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869460 sample_title: Patient 5 surgical resection - post treatment_2 source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 5; protocol: post-treatment surgical resection; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869461 sample_title: Patient 5 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 5; protocol: post-treatment surgical resection; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869461 sample_title: Patient 5 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 5; protocol: post-treatment surgical resection; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869462 sample_title: Patient 6 needle core biospy - pre treatment_2 source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 6; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low
Included in derived sample grouping as tumor sample
sample_accession: GSM2869462 sample_title: Patient 6 needle core biospy - pre treatment_2 source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 6; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low
tumor sample (case)
sample_accession: GSM2869463 sample_title: Patient 6 surgical resection - post treatment_2 source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 6; protocol: post-treatment surgical resection; tumor sample subtype: claudin low
Included in derived sample grouping as tumor sample
sample_accession: GSM2869463 sample_title: Patient 6 surgical resection - post treatment_2 source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 6; protocol: post-treatment surgical resection; tumor sample subtype: claudin low
normal tissue (control)
sample_accession: GSM2869464 sample_title: Patient 7 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 7; protocol: pre-treatment needle core biospy; tumor sample subtype: normal breast
Included in derived sample grouping as normal tissue
sample_accession: GSM2869464 sample_title: Patient 7 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 7; protocol: pre-treatment needle core biospy; tumor sample subtype: normal breast
normal tissue (control)
sample_accession: GSM2869465 sample_title: Patient 7 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 7; protocol: post-treatment surgical resection; tumor sample subtype: normal breast
Included in derived sample grouping as normal tissue
sample_accession: GSM2869465 sample_title: Patient 7 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 7; protocol: post-treatment surgical resection; tumor sample subtype: normal breast
tumor sample (case)
sample_accession: GSM2869466 sample_title: Patient 8 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 8; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low
Included in derived sample grouping as tumor sample
sample_accession: GSM2869466 sample_title: Patient 8 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 8; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low
tumor sample (case)
sample_accession: GSM2869467 sample_title: Patient 8 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 8; protocol: post-treatment surgical resection; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869467 sample_title: Patient 8 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 8; protocol: post-treatment surgical resection; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869468 sample_title: Patient 1 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 1; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869468 sample_title: Patient 1 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 1; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869469 sample_title: Patient 1 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 1; protocol: post-treatment surgical resection; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869469 sample_title: Patient 1 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 1; protocol: post-treatment surgical resection; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869470 sample_title: Patient 2 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 2; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869470 sample_title: Patient 2 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 2; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869471 sample_title: Patient 2 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 2; protocol: post-treatment surgical resection; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869471 sample_title: Patient 2 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 2; protocol: post-treatment surgical resection; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869472 sample_title: Patient 9 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 9; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869472 sample_title: Patient 9 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 9; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
normal tissue (control)
sample_accession: GSM2869473 sample_title: Patient 9 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 9; protocol: post-treatment surgical resection; tumor sample subtype: normal breast
Included in derived sample grouping as normal tissue
sample_accession: GSM2869473 sample_title: Patient 9 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 9; protocol: post-treatment surgical resection; tumor sample subtype: normal breast
tumor sample (case)
sample_accession: GSM2869474 sample_title: Patient 10 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 10; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low
Included in derived sample grouping as tumor sample
sample_accession: GSM2869474 sample_title: Patient 10 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 10; protocol: pre-treatment needle core biospy; tumor sample subtype: claudin low
tumor sample (case)
sample_accession: GSM2869475 sample_title: Patient 10 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 10; protocol: post-treatment surgical resection; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869475 sample_title: Patient 10 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 10; protocol: post-treatment surgical resection; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869476 sample_title: Patient 4 Needle Core Biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 4; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869476 sample_title: Patient 4 Needle Core Biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 4; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869477 sample_title: Patient 4 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 4; protocol: post-treatment surgical resection; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869477 sample_title: Patient 4 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 4; protocol: post-treatment surgical resection; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869478 sample_title: Patient 3 Needle Core Biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 3; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869478 sample_title: Patient 3 Needle Core Biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 3; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869479 sample_title: Patient 3 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 3; protocol: post-treatment surgical resection; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869479 sample_title: Patient 3 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 3; protocol: post-treatment surgical resection; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869480 sample_title: Patient 11 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 11; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
Included in derived sample grouping as tumor sample
sample_accession: GSM2869480 sample_title: Patient 11 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 11; protocol: pre-treatment needle core biospy; tumor sample subtype: basal
tumor sample (case)
sample_accession: GSM2869481 sample_title: Patient 11 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 11; protocol: post-treatment surgical resection; tumor sample subtype: claudin low
Included in derived sample grouping as tumor sample
sample_accession: GSM2869481 sample_title: Patient 11 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 11; protocol: post-treatment surgical resection; tumor sample subtype: claudin low
normal tissue (control)
sample_accession: GSM2869482 sample_title: Patient 12 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 12; protocol: pre-treatment needle core biospy; tumor sample subtype: normal breast
Included in derived sample grouping as normal tissue
sample_accession: GSM2869482 sample_title: Patient 12 needle core biopsy - pre treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 12; protocol: pre-treatment needle core biospy; tumor sample subtype: normal breast
normal tissue (control)
sample_accession: GSM2869483 sample_title: Patient 12 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 12; protocol: post-treatment surgical resection; tumor sample subtype: normal breast
Included in derived sample grouping as normal tissue
sample_accession: GSM2869483 sample_title: Patient 12 surgical resection - post treatment source_name: breast carcinoma characteristics: disease state: TNBC; individual: Patient 12; protocol: post-treatment surgical resection; tumor sample subtype: normal breast
Original dataset metadata, sample metadata, source links, and GEO data availability flags.
Planned trusted source for processed count availability.
Planned source for curated expression experiment links.
Publication context when PubMed identifiers are already known.
No project feedback stored for this dataset.
dataset_accession: GSE107502 dataset_title: Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 (RNA-Seq) organism: Homo sapiens assay_type: bulk RNA-seq processed_data_available: true raw_data_available: true submission_date: 2017-11-29 last_update_date: 2019-03-27 organization_name: University of North Carolina School of Medicine department: Pharmacology public_date: 2017-11-29 experiment_types: Expression profiling by high throughput sequencing platforms: GPL11154 Illumina HiSeq 2000 (Homo sapiens) sub_series: Not available bioproject: PRJNA420378 supplementary_files: TXT: GSE107502_LCCC1122_DESeq2_trametinibresponse.txt.gz; TXT: GSE107502_LCCC1122_normalizedLog2RSEM.txt.gz; TXT: GSE107502_LCCC1122_rawRSEM.txt.gz series_type: SubSeries
No warnings
Samples currently treated as the comparison case group.
Samples currently treated as controls or baseline.
Samples with no explicit case or control marker.
No samples
Samples excluded from grouping by hard exclusion rules.
No samples
Samples that need manual review before trusting grouping.
No samples
No review decisions have been stored for this dataset.