Siftome Phase 3L

GSE146719

Transcriptome analysis in hepatocellular carcinoma (HCC) tissues

Not suitable Dataset does not meet the current suitability threshold.
Sample grouping CSV Contrast CSV DESeq2 metadata CSV R handoff notes Handoff report Download instructions Open GEO dataset
Source
GEO
Search intent
Patient tissue tumor-vs-normal
Intent behavior
search-intent-behavior-v1
Submission date
2020-03-10
Last update
2023-02-28
Organization
Eastern Hepatobiliary Surgery Hospital
Department
Not available
Public date
2023-02-28
Experiment types
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platforms
GPL20795 HiSeq X Ten (Homo sapiens)
Series type
Series
SubSeries
Not available
BioProject
PRJNA611758
Supplementary files
TXT: GSE146719_All.Counts.miRNA.txt.gz; TXT: GSE146719_All.counts.RNA.txt.gz
Organism
Homo sapiens
Assay
bulk RNA-seq
Samples
12
Study design
Tumor vs unmatched normal
Specimen/source
Tissue
Scoring version
intent-aware-scoring-v15
Ranking batch
b69568dd1e4fe1b9ee2d880bf5495d748a7e4c5c11e4107f02528c3be0e76012
Ranking created
2026-06-05T20:20:27.088676Z
Warning version
intent-aware-warnings-v2

Current Intent Interpretation

Patient tissue tumor-vs-normal

Expectations

Organism
Homo sapiens
Assay
bulk RNA-seq
Specimen/source
patient tissue or biopsy
Controls
matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control

Rules

Default filters
Human only; Bulk RNA-seq only; Tumor-normal only; Tissue or biopsy only; Hide biofluid/model systems
Warning rules
missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
Score caps
non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
Downgraded contexts
microarray unless explicitly enabled, biofluid-only datasets, cell-line datasets, organoid datasets, xenograft or PDX datasets, non-colorectal disease contexts, or treatment-only experiments

Study Classification

Tumor vs unmatched normal Tissue

Analysis Readiness

Review before analysis
94% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

7/10 pts

Metadata quality is usable, but still deserves review.

Blockers

  • Secondary RNA assay context should be analyzed separately from ordinary bulk RNA-seq.

Next Steps

  • Review blockers and update sample grouping or dataset selection before analysis.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Still scan the grouping table for biology-specific ambiguity.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source links preserved

Ready

The dataset and sample accessions can be linked back to GEO.

Keep GEO dataset and sample links with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

  • Analysis readiness has blockers that must be resolved before DE.
  • Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Patient tissue tumor-vs-normal
Not suitable Dataset does not meet the current suitability threshold.

Score Components

  • relevance 50% Organism normalized. Assay type normalized.
  • comparison suitability 0% Tumor and normal sample groups detected. No excluded sample type flags detected. Tumor/normal design boosted for colorectal tumor-vs-normal tissue triage. Patient tissue or biopsy specimens boosted for tissue comparison triage. Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking. Non-colorectal cancer context downgraded for colorectal tumor-vs-normal tissue ranking.
  • metadata quality 70% Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata was not normalized. Tissue clarity: Tissue metadata was not normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.
  • data availability 100% Processed data available. Raw data available.
  • overall 34% Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability. Overall score capped because comparison suitability is weak for the selected search intent. Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq. Overall score capped because tumor/normal grouping is from a non-colorectal cancer context.

Derived Classifications

  • Organism Homo sapiens Organism remains rule-derived: Homo sapiens.
  • Assay bulk RNA-seq Assay remains rule-derived: bulk RNA-seq.
  • Study design Tumor vs unmatched normal Study design remains rule-derived: Tumor vs unmatched normal.
  • Specimen/source Tissue Specimen/source remains rule-derived: Tissue.
  • Likely case group tumor sample 6 samples
  • Likely control group normal tissue 6 samples

Warnings

  • SECONDARY_ASSAY_CONTEXT warning Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.
  • DISEASE_LABEL_UNCLEAR warning Disease or condition label could not be normalized.
  • TISSUE_TYPE_MISSING warning Tissue or cell type could not be normalized.

Intent Interpretation

  • Active intent Patient tissue tumor-vs-normal Ranks human colorectal tissue or biopsy cohorts where tumor samples can be compared with normal controls.
  • Organism expectation Homo sapiens Dataset organism is interpreted as Homo sapiens.
  • Assay expectation bulk RNA-seq Dataset assay is interpreted as bulk RNA-seq.
  • Specimen assumption patient tissue or biopsy Derived specimen/source is Tissue.
  • Control-group assumption matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control Derived study design is Tumor vs unmatched normal; likely groups are tumor sample vs normal tissue.
  • Score caps Applied when matching conditions are present non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
  • Warning rules 3 active warnings missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
  • Downgrade or exclusion reason Downgraded disease context: not a colorectal/GI cancer cohort. Derived from current-intent ranking reasons and warnings.

Applied Review Decisions

No active review decisions affect this ranking.

Ranking Facts

  • Recommendation Not suitable Dataset does not meet the current suitability threshold.
  • Supporting fact Tumor vs unmatched normal · Tissue · suitability 0%. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized assay: bulk RNA-seq is the active assay expectation. Contributed to match or upgrade evidence.
  • Supporting fact Downgraded disease context: not a colorectal/GI cancer cohort. Contributed to match or upgrade evidence.
  • Supporting fact Processed data is available for downstream review. Contributed to match or upgrade evidence.
  • Supporting fact 3 warnings require review. Contributed to match or upgrade evidence.
  • Caution fact Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected. Contributed to downgrade or manual-review evidence.
  • Caution fact Disease or condition label could not be normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Tissue or cell type could not be normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Non-colorectal cancer context downgraded for colorectal tumor-vs-normal tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Disease clarity: Disease or condition metadata was not normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Tissue clarity: Tissue metadata was not normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because comparison suitability is weak for the selected search intent. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because tumor/normal grouping is from a non-colorectal cancer context. Contributed to downgrade or manual-review evidence.
  • Caution fact Downgraded disease context: not a colorectal/GI cancer cohort. Contributed to downgrade or manual-review evidence.
  • Caution fact Comparison suitability score is below the Phase 1 recommended threshold. Contributed to downgrade or manual-review evidence.

Manual Corrections

0 active

Source Evidence

4 sources

GEO

Primary source

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Dataset accession
GSE146719
Sample records
12 GSM samples
  • GEO has priority for original metadata under the Phase 3J source rules.
  • Processed data: available.
  • Raw data: available.
  • No external source conflict is present in the current runtime data.

recount3

Not imported

Planned trusted source for processed count availability.

GEO accession
GSE146719
  • No recount3 project identifier has been imported for this dataset.
  • Once imported, recount3 has priority for processed count availability.
  • The recount3 source filter excludes this dataset until that linkage exists.
No recount3 sync data available.

Expression Atlas

Not imported

Planned source for curated expression experiment links.

GEO accession
GSE146719
  • No Expression Atlas experiment identifier has been imported for this dataset.
  • Once imported, Expression Atlas has priority for curated expression experiment links.
  • The Expression Atlas source filter excludes this dataset until that linkage exists.
No Expression Atlas sync data available.

PubMed

Unavailable

Publication context when PubMed identifiers are already known.

GEO accession
GSE146719
  • No PubMed identifier is present in the current runtime metadata.
  • No live PubMed search is performed from the dataset detail page.
No publication identifier imported.

Dataset Feedback

0 stored

Original GEO Metadata

dataset_accession: GSE146719
dataset_title: Transcriptome analysis in hepatocellular carcinoma (HCC) tissues
organism: Homo sapiens
assay_type: bulk RNA-seq
processed_data_available: true
raw_data_available: true
submission_date: 2020-03-10
last_update_date: 2023-02-28
organization_name: Eastern Hepatobiliary Surgery Hospital
department: Not available
public_date: 2023-02-28
experiment_types: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
platforms: GPL20795 HiSeq X Ten (Homo sapiens)
sub_series: Not available
bioproject: PRJNA611758
supplementary_files: TXT: GSE146719_All.Counts.miRNA.txt.gz; TXT: GSE146719_All.counts.RNA.txt.gz
series_type: Series

Why It Matched

  • Tumor vs unmatched normal · Tissue · suitability 0%.
  • Prioritized assay: bulk RNA-seq is the active assay expectation.
  • Downgraded disease context: not a colorectal/GI cancer cohort.
  • Processed data is available for downstream review.
  • 3 warnings require review.

Why It May Not Be Suitable

  • Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.
  • Disease or condition label could not be normalized.
  • Tissue or cell type could not be normalized.
  • Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
  • Non-colorectal cancer context downgraded for colorectal tumor-vs-normal tissue ranking.
  • Missing or unclear metadata: Disease clarity: Disease or condition metadata was not normalized.
  • Missing or unclear metadata: Tissue clarity: Tissue metadata was not normalized.
  • Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.
  • Overall score capped because tumor/normal grouping is from a non-colorectal cancer context.
  • Downgraded disease context: not a colorectal/GI cancer cohort.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Warnings

  • warning SECONDARY_ASSAY_CONTEXT Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.
  • warning DISEASE_LABEL_UNCLEAR Disease or condition label could not be normalized.
  • warning TISSUE_TYPE_MISSING Tissue or cell type could not be normalized.

Normalized Fields

14 fields
Field Value Source Origin Confidence Evidence Reason
assay_type bulk RNA-seq dataset GSE146719 Runtime Siftome inference GEO:dataset:GSE146719:dc2eb2b4b030f638a3b72305fb4b887166fe0eefa8d789720979fc6c2d79798d high confidence bulk rna-seq dataset_accession: GSE146719 dataset_title: Transcriptome analysis in hepatocellular carcinoma (HCC) tissues organism: Homo sapiens assay_type: bulk RNA-seq processed_data_avail... keyword match keyword match: bulk rna-seq
organism Homo sapiens dataset GSE146719 Runtime Siftome inference GEO:dataset:GSE146719:dc2eb2b4b030f638a3b72305fb4b887166fe0eefa8d789720979fc6c2d79798d high confidence homo sapiens dataset_accession: GSE146719 dataset_title: Transcriptome analysis in hepatocellular carcinoma (HCC) tissues organism: Homo sapiens assay_type: bulk RNA-seq processed_data_avail... keyword match keyword match: homo sapiens
sample_type tumor sample sample GSM4404637 Runtime Siftome inference GEO:sample:GSM4404637:6a83f5e79b28b836fead8a716fe18d8af9ce7dc7d74b5e11573a70036d323e57 low confidence tumor sample_accession: GSM4404637 sample_title: HCC tissue 1 [RNA-seq] source_name: 138011T characteristics: tissue type: tumor tissue HCC tissue 1 [RNA-seq] controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM4404638 Runtime Siftome inference GEO:sample:GSM4404638:a46704ac83805f4276261217c4fb474fd50afcf3d7656c90a2e4391c30fac192 medium confidence non-tumor sample_accession: GSM4404638 sample_title: pared non-tumorous tissue 1 [RNA-seq] source_name: 138011N characteristics: tissue type: paird non-tumor tissue pared non-tumorous tis... controlled vocabulary controlled vocabulary sample type match: non-tumor
sample_type tumor sample sample GSM4404639 Runtime Siftome inference GEO:sample:GSM4404639:15dbb110097b312173a6d740100bfeea1df53fa790b70e1ffc9a7b49ac7abfc6 low confidence tumor sample_accession: GSM4404639 sample_title: HCC tissue 2 [RNA-seq] source_name: 138228T characteristics: tissue type: tumor tissue HCC tissue 2 [RNA-seq] controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM4404640 Runtime Siftome inference GEO:sample:GSM4404640:0cb4e26880efb4812ed3f85d60d2bf3fc3ed32d5277fff0a430286b262a9fd07 medium confidence non-tumor sample_accession: GSM4404640 sample_title: pared non-tumorous tissue 2 [RNA-seq] source_name: 138228N characteristics: tissue type: paird non-tumor tissue pared non-tumorous tis... controlled vocabulary controlled vocabulary sample type match: non-tumor
sample_type tumor sample sample GSM4404641 Runtime Siftome inference GEO:sample:GSM4404641:34c3c6b157fa305012164115bc141441e02466d3cbcf0cb82a53d76f3d7fbc8b low confidence tumor sample_accession: GSM4404641 sample_title: HCC tissue 3 [RNA-seq] source_name: 138239T characteristics: tissue type: tumor tissue HCC tissue 3 [RNA-seq] controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM4404642 Runtime Siftome inference GEO:sample:GSM4404642:8f45587c8a4f13cd33c8d5d4b67a0289cc7cac72b6140970fad8c8c5a13f7b97 medium confidence non-tumor sample_accession: GSM4404642 sample_title: pared non-tumorous tissue 3 [RNA-seq] source_name: 138239N characteristics: tissue type: paird non-tumor tissue pared non-tumorous tis... controlled vocabulary controlled vocabulary sample type match: non-tumor
sample_type tumor sample sample GSM4404643 Runtime Siftome inference GEO:sample:GSM4404643:818d9695398d5d5909f91bbbfd0e2a4a575d0f1cd37f463819b4ad95fa04e864 low confidence tumor sample_accession: GSM4404643 sample_title: HCC tissue 1 [miRNA-seq] source_name: 138011T characteristics: tissue type: tumor tissue HCC tissue 1 [miRNA-seq] controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM4404644 Runtime Siftome inference GEO:sample:GSM4404644:83a245f43864a03e9342915a342936dc3756e02108df2442735f58df8546034c medium confidence non-tumor sample_accession: GSM4404644 sample_title: pared non-tumorous tissue 1 [miRNA-seq] source_name: 138011N characteristics: tissue type: paird non-tumor tissue pared non-tumorous t... controlled vocabulary controlled vocabulary sample type match: non-tumor
sample_type tumor sample sample GSM4404645 Runtime Siftome inference GEO:sample:GSM4404645:c0c965aca3d2840a7d0806a0032e42403c10a8591e988b3dbf4ad054d7de3d01 low confidence tumor sample_accession: GSM4404645 sample_title: HCC tissue 2 [miRNA-seq] source_name: 138228T characteristics: tissue type: tumor tissue HCC tissue 2 [miRNA-seq] controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM4404646 Runtime Siftome inference GEO:sample:GSM4404646:5dfd2e54c56fcc22e463807a11cb617f0c7387bfd21e03cede4b81921ff7fa34 medium confidence non-tumor sample_accession: GSM4404646 sample_title: pared non-tumorous tissue 2 [miRNA-seq] source_name: 138228N characteristics: tissue type: paird non-tumor tissue pared non-tumorous t... controlled vocabulary controlled vocabulary sample type match: non-tumor
sample_type tumor sample sample GSM4404647 Runtime Siftome inference GEO:sample:GSM4404647:1e078e179b3bb322baa1f5c148574237b8200e39b9683e746d8d4c76095e5ef0 low confidence tumor sample_accession: GSM4404647 sample_title: HCC tissue 3 [miRNA-seq] source_name: 138239T characteristics: tissue type: tumor tissue HCC tissue 3 [miRNA-seq] controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM4404648 Runtime Siftome inference GEO:sample:GSM4404648:cb3a64ada768d4f260aaec3712eac2d4810ee804f526636cf7db190939e83b70 medium confidence non-tumor sample_accession: GSM4404648 sample_title: pared non-tumorous tissue 3 [miRNA-seq] source_name: 138239N characteristics: tissue type: paird non-tumor tissue pared non-tumorous t... controlled vocabulary controlled vocabulary sample type match: non-tumor

Sample Group Preview

Possible case samples

Samples currently treated as the comparison case group.

6
  • GSM4404637 HCC tissue 1 [RNA-seq] tumor sample Case marker detected. 138011T tissue type: tumor tissue
  • GSM4404639 HCC tissue 2 [RNA-seq] tumor sample Case marker detected. 138228T tissue type: tumor tissue
  • GSM4404641 HCC tissue 3 [RNA-seq] tumor sample Case marker detected. 138239T tissue type: tumor tissue
  • GSM4404643 HCC tissue 1 [miRNA-seq] tumor sample Case marker detected. 138011T tissue type: tumor tissue
  • GSM4404645 HCC tissue 2 [miRNA-seq] tumor sample Case marker detected. 138228T tissue type: tumor tissue
  • GSM4404647 HCC tissue 3 [miRNA-seq] tumor sample Case marker detected. 138239T tissue type: tumor tissue

Possible control samples

Samples currently treated as controls or baseline.

6
  • GSM4404638 pared non-tumorous tissue 1 [RNA-seq] normal tissue Control marker detected. 138011N tissue type: paird non-tumor tissue
  • GSM4404640 pared non-tumorous tissue 2 [RNA-seq] normal tissue Control marker detected. 138228N tissue type: paird non-tumor tissue
  • GSM4404642 pared non-tumorous tissue 3 [RNA-seq] normal tissue Control marker detected. 138239N tissue type: paird non-tumor tissue
  • GSM4404644 pared non-tumorous tissue 1 [miRNA-seq] normal tissue Control marker detected. 138011N tissue type: paird non-tumor tissue
  • GSM4404646 pared non-tumorous tissue 2 [miRNA-seq] normal tissue Control marker detected. 138228N tissue type: paird non-tumor tissue
  • GSM4404648 pared non-tumorous tissue 3 [miRNA-seq] normal tissue Control marker detected. 138239N tissue type: paird non-tumor tissue

Unassigned samples

Samples with no explicit case or control marker.

0

No samples

Excluded samples

Samples excluded from grouping by hard exclusion rules.

0

No samples

Ambiguous samples

Samples that need manual review before trusting grouping.

0

No samples

Metadata Quality Components

Persisted metadata quality

70 pts
Clarity
70%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata was not normalized. Tissue clarity: Tissue metadata was not normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Detected Sample Groups

tumor sample

6 samples
  • GSM4404637 HCC tissue 1 [RNA-seq] 138011T tissue type: tumor tissue
  • GSM4404639 HCC tissue 2 [RNA-seq] 138228T tissue type: tumor tissue
  • GSM4404641 HCC tissue 3 [RNA-seq] 138239T tissue type: tumor tissue
  • GSM4404643 HCC tissue 1 [miRNA-seq] 138011T tissue type: tumor tissue
  • GSM4404645 HCC tissue 2 [miRNA-seq] 138228T tissue type: tumor tissue
  • GSM4404647 HCC tissue 3 [miRNA-seq] 138239T tissue type: tumor tissue

normal tissue

6 samples
  • GSM4404638 pared non-tumorous tissue 1 [RNA-seq] 138011N tissue type: paird non-tumor tissue
  • GSM4404640 pared non-tumorous tissue 2 [RNA-seq] 138228N tissue type: paird non-tumor tissue
  • GSM4404642 pared non-tumorous tissue 3 [RNA-seq] 138239N tissue type: paird non-tumor tissue
  • GSM4404644 pared non-tumorous tissue 1 [miRNA-seq] 138011N tissue type: paird non-tumor tissue
  • GSM4404646 pared non-tumorous tissue 2 [miRNA-seq] 138228N tissue type: paird non-tumor tissue
  • GSM4404648 pared non-tumorous tissue 3 [miRNA-seq] 138239N tissue type: paird non-tumor tissue

Score Breakdown

50%

relevance

  • Organism normalized.
  • Assay type normalized.
0%

comparison suitability

  • Tumor and normal sample groups detected.
  • No excluded sample type flags detected.
  • Tumor/normal design boosted for colorectal tumor-vs-normal tissue triage.
  • Patient tissue or biopsy specimens boosted for tissue comparison triage.
  • Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
  • Non-colorectal cancer context downgraded for colorectal tumor-vs-normal tissue ranking.
70%

metadata quality

  • Sample source clarity: All samples have source metadata and clear GSE/GSM accessions.
  • Group clarity: Rule-based grouping found both case and control samples.
  • Disease clarity: Disease or condition metadata was not normalized.
  • Tissue clarity: Tissue metadata was not normalized.
  • Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Replicate clarity: No pooled sample or technical replicate flags detected.
  • Data availability clarity: Dataset-level processed or raw data availability is explicit.
100%

data availability

  • Processed data available.
  • Raw data available.
34%

overall

  • Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.
  • Overall score capped because tumor/normal grouping is from a non-colorectal cancer context.

Sample Links

12 samples

Review Audit Trail

0 decisions

No review decisions have been stored for this dataset.