Siftome Phase 3L

GSE205094

CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [miRNA-seq]

Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.
Sample grouping CSV Contrast CSV DESeq2 metadata CSV R handoff notes Handoff report Download instructions Open GEO dataset
Source
GEO
Search intent
Patient tissue tumor-vs-normal
Intent behavior
search-intent-behavior-v1
Submission date
2022-05-30
Last update
2022-06-04
Organization
Nanjing Medical University
Department
Department of Medical Genetics
Public date
2022-06-04
Experiment types
Non-coding RNA profiling by high throughput sequencing
Platforms
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Series type
SubSeries
SubSeries
Not available
BioProject
Not available
Supplementary files
TXT: GSE205094_count.txt.gz
Organism
Homo sapiens
Assay
bulk RNA-seq
Samples
10
Study design
Tumor vs matched normal
Specimen/source
Tissue
Scoring version
intent-aware-scoring-v15
Ranking batch
b69568dd1e4fe1b9ee2d880bf5495d748a7e4c5c11e4107f02528c3be0e76012
Ranking created
2026-06-05T20:20:27.088676Z
Warning version
intent-aware-warnings-v2

Current Intent Interpretation

Patient tissue tumor-vs-normal

Expectations

Organism
Homo sapiens
Assay
bulk RNA-seq
Specimen/source
patient tissue or biopsy
Controls
matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control

Rules

Default filters
Human only; Bulk RNA-seq only; Tumor-normal only; Tissue or biopsy only; Hide biofluid/model systems
Warning rules
missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
Score caps
non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
Downgraded contexts
microarray unless explicitly enabled, biofluid-only datasets, cell-line datasets, organoid datasets, xenograft or PDX datasets, non-colorectal disease contexts, or treatment-only experiments

Study Classification

Tumor vs matched normal Tissue

Analysis Readiness

Review before analysis
97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

  • Secondary RNA assay context should be analyzed separately from ordinary bulk RNA-seq.

Next Steps

  • Review blockers and update sample grouping or dataset selection before analysis.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Still scan the grouping table for biology-specific ambiguity.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source links preserved

Ready

The dataset and sample accessions can be linked back to GEO.

Keep GEO dataset and sample links with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

  • Analysis readiness has blockers that must be resolved before DE.
  • Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Patient tissue tumor-vs-normal
Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.

Score Components

  • relevance 100% Disease or condition metadata normalized. Organism normalized. Assay type normalized. Tissue metadata normalized.
  • comparison suitability 55% Case and control sample groups detected: colorectal cancer vs normal tissue. No excluded sample type flags detected. Matched tumor/normal design boosted for colorectal tumor-vs-normal tissue triage. Patient tissue or biopsy specimens boosted for tissue comparison triage. Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking. Colorectal, colon, rectal, or CRC disease context boosted for tumor-vs-normal tissue ranking.
  • metadata quality 100% Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Tissue metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.
  • data availability 100% Processed data available. Raw data available.
  • overall 50% Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability. Overall score capped because comparison suitability is weak for the selected search intent. Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.

Derived Classifications

  • Organism Homo sapiens Organism remains rule-derived: Homo sapiens.
  • Assay bulk RNA-seq Assay remains rule-derived: bulk RNA-seq.
  • Study design Tumor vs matched normal Study design remains rule-derived: Tumor vs matched normal.
  • Specimen/source Tissue Specimen/source remains rule-derived: Tissue.
  • Likely case group colorectal cancer 5 samples
  • Likely control group normal tissue 5 samples

Warnings

  • SECONDARY_ASSAY_CONTEXT warning Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.

Intent Interpretation

  • Active intent Patient tissue tumor-vs-normal Ranks human colorectal tissue or biopsy cohorts where tumor samples can be compared with normal controls.
  • Organism expectation Homo sapiens Dataset organism is interpreted as Homo sapiens.
  • Assay expectation bulk RNA-seq Dataset assay is interpreted as bulk RNA-seq.
  • Specimen assumption patient tissue or biopsy Derived specimen/source is Tissue.
  • Control-group assumption matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control Derived study design is Tumor vs matched normal; likely groups are colorectal cancer vs normal tissue.
  • Score caps Applied when matching conditions are present non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
  • Warning rules 1 active warning missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
  • Downgrade or exclusion reason 1 warning require review. Derived from current-intent ranking reasons and warnings.

Applied Review Decisions

No active review decisions affect this ranking.

Ranking Facts

  • Recommendation Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.
  • Supporting fact Tumor vs matched normal · Tissue · suitability 55%. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized for patient tissue tumor-vs-normal triage. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized assay: bulk RNA-seq is the active assay expectation. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized disease context: colorectal, colon, rectal, or CRC metadata detected. Contributed to match or upgrade evidence.
  • Supporting fact Processed data is available for downstream review. Contributed to match or upgrade evidence.
  • Supporting fact 1 warning require review. Contributed to match or upgrade evidence.
  • Caution fact Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected. Contributed to downgrade or manual-review evidence.
  • Caution fact Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because comparison suitability is weak for the selected search intent. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq. Contributed to downgrade or manual-review evidence.
  • Caution fact Comparison suitability score is below the Phase 1 recommended threshold. Contributed to downgrade or manual-review evidence.

Manual Corrections

0 active

Source Evidence

4 sources

GEO

Primary source

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Dataset accession
GSE205094
Sample records
10 GSM samples
  • GEO has priority for original metadata under the Phase 3J source rules.
  • Processed data: available.
  • Raw data: available.
  • No external source conflict is present in the current runtime data.

recount3

Not imported

Planned trusted source for processed count availability.

GEO accession
GSE205094
  • No recount3 project identifier has been imported for this dataset.
  • Once imported, recount3 has priority for processed count availability.
  • The recount3 source filter excludes this dataset until that linkage exists.
No recount3 sync data available.

Expression Atlas

Not imported

Planned source for curated expression experiment links.

GEO accession
GSE205094
  • No Expression Atlas experiment identifier has been imported for this dataset.
  • Once imported, Expression Atlas has priority for curated expression experiment links.
  • The Expression Atlas source filter excludes this dataset until that linkage exists.
No Expression Atlas sync data available.

PubMed

Unavailable

Publication context when PubMed identifiers are already known.

GEO accession
GSE205094
  • No PubMed identifier is present in the current runtime metadata.
  • No live PubMed search is performed from the dataset detail page.
No publication identifier imported.

Dataset Feedback

0 stored

Original GEO Metadata

dataset_accession: GSE205094
dataset_title: CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [miRNA-seq]
organism: Homo sapiens
assay_type: bulk RNA-seq
processed_data_available: true
raw_data_available: true
submission_date: 2022-05-30
last_update_date: 2022-06-04
organization_name: Nanjing Medical University
department: Department of Medical Genetics
public_date: 2022-06-04
experiment_types: Non-coding RNA profiling by high throughput sequencing
platforms: GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
sub_series: Not available
bioproject: Not available
supplementary_files: TXT: GSE205094_count.txt.gz
series_type: SubSeries

Why It Matched

  • Tumor vs matched normal · Tissue · suitability 55%.
  • Prioritized for patient tissue tumor-vs-normal triage.
  • Prioritized assay: bulk RNA-seq is the active assay expectation.
  • Prioritized disease context: colorectal, colon, rectal, or CRC metadata detected.
  • Processed data is available for downstream review.
  • 1 warning require review.

Why It May Not Be Suitable

  • Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.
  • Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
  • Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Warnings

  • warning SECONDARY_ASSAY_CONTEXT Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.

Normalized Fields

34 fields
Field Value Source Origin Confidence Evidence Reason
assay_type bulk RNA-seq dataset GSE205094 Runtime Siftome inference GEO:dataset:GSE205094:92eea0333ecaef4020e4e377af8bc6b482c3296f80ea3f3d79c0f33d7130f647 high confidence bulk rna-seq dataset_accession: GSE205094 dataset_title: CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [miRNA-seq]... keyword match keyword match: bulk rna-seq
disease colorectal cancer dataset GSE205094 Runtime Siftome inference GEO:dataset:GSE205094:92eea0333ecaef4020e4e377af8bc6b482c3296f80ea3f3d79c0f33d7130f647 high confidence colorectal cancer dataset_accession: GSE205094 dataset_title: CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [miRNA-seq]... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6205120 Runtime Siftome inference GEO:sample:GSM6205120:28fea2c937ecee0deaee352a660ee6b347e0a4a4d15b715ab27a2ffa1f7a3fd4 high confidence colorectal cancer sample_accession: GSM6205120 sample_title: CRC-C1 (miRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: colorec... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6205121 Runtime Siftome inference GEO:sample:GSM6205121:55a691866124b21cedf93a645d8e1684dfb2a3bde5526361e53c095f8250a8bc high confidence colorectal cancer sample_accession: GSM6205121 sample_title: adjacent normal tissue-N1 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6205122 Runtime Siftome inference GEO:sample:GSM6205122:0c0c3bc3f7e93d41fa0cfaef3da8ed1cac8758b40ed87f2bf2bca95e0c6e88b2 high confidence colorectal cancer sample_accession: GSM6205122 sample_title: CRC-C2 (miRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: colorec... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6205123 Runtime Siftome inference GEO:sample:GSM6205123:3df2ea0a9c570ef6b34b8b1a4aa4a8a6f450c848e798b0318da3ce247a4b6827 high confidence colorectal cancer sample_accession: GSM6205123 sample_title: adjacent normal tissue-N2 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6205124 Runtime Siftome inference GEO:sample:GSM6205124:6aeb507a91fac511655d2b6cbb668f1ede257c22f9c85c06fdba84aa534b8325 high confidence colorectal cancer sample_accession: GSM6205124 sample_title: CRC-C4 (miRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: colorec... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6205125 Runtime Siftome inference GEO:sample:GSM6205125:6afe29a166b5a0511fa21d10430f1f5683051ddbd9ce6ef42701202bedb5bcde high confidence colorectal cancer sample_accession: GSM6205125 sample_title: adjacent normal tissue-N4 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6205126 Runtime Siftome inference GEO:sample:GSM6205126:8cd48a9a90caa4b514d678e8b1813f368b5fb1b1b61b76b371afbf2badceb07d high confidence colorectal cancer sample_accession: GSM6205126 sample_title: CRC-C5 (miRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: colorec... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6205127 Runtime Siftome inference GEO:sample:GSM6205127:86207ea79a51963c1336ddab1f8a3f3174ded1289a530b5743653469cc6e6c2d high confidence colorectal cancer sample_accession: GSM6205127 sample_title: adjacent normal tissue-N5 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6205128 Runtime Siftome inference GEO:sample:GSM6205128:3cad681123a8e220180808b9e9caf9e0b31025a6e669b1b51dc36a2170560ddb high confidence colorectal cancer sample_accession: GSM6205128 sample_title: CRC-C6 (miRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: colorec... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6205129 Runtime Siftome inference GEO:sample:GSM6205129:059140b8690484c606ab6399f3eecda783d51555d1b36944d647227e38129e1b high confidence colorectal cancer sample_accession: GSM6205129 sample_title: adjacent normal tissue-N6 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary disease match: colorectal cancer
normal_tissue_type adjacent normal sample GSM6205121 Runtime Siftome inference GEO:sample:GSM6205121:55a691866124b21cedf93a645d8e1684dfb2a3bde5526361e53c095f8250a8bc high confidence adjacent normal sample_accession: GSM6205121 sample_title: adjacent normal tissue-N1 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
normal_tissue_type adjacent normal sample GSM6205123 Runtime Siftome inference GEO:sample:GSM6205123:3df2ea0a9c570ef6b34b8b1a4aa4a8a6f450c848e798b0318da3ce247a4b6827 high confidence adjacent normal sample_accession: GSM6205123 sample_title: adjacent normal tissue-N2 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
normal_tissue_type adjacent normal sample GSM6205125 Runtime Siftome inference GEO:sample:GSM6205125:6afe29a166b5a0511fa21d10430f1f5683051ddbd9ce6ef42701202bedb5bcde high confidence adjacent normal sample_accession: GSM6205125 sample_title: adjacent normal tissue-N4 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
normal_tissue_type adjacent normal sample GSM6205127 Runtime Siftome inference GEO:sample:GSM6205127:86207ea79a51963c1336ddab1f8a3f3174ded1289a530b5743653469cc6e6c2d high confidence adjacent normal sample_accession: GSM6205127 sample_title: adjacent normal tissue-N5 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
normal_tissue_type adjacent normal sample GSM6205129 Runtime Siftome inference GEO:sample:GSM6205129:059140b8690484c606ab6399f3eecda783d51555d1b36944d647227e38129e1b high confidence adjacent normal sample_accession: GSM6205129 sample_title: adjacent normal tissue-N6 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
organism Homo sapiens dataset GSE205094 Runtime Siftome inference GEO:dataset:GSE205094:92eea0333ecaef4020e4e377af8bc6b482c3296f80ea3f3d79c0f33d7130f647 high confidence homo sapiens dataset_accession: GSE205094 dataset_title: CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [miRNA-seq]... keyword match keyword match: homo sapiens
sample_type normal tissue sample GSM6205121 Runtime Siftome inference GEO:sample:GSM6205121:55a691866124b21cedf93a645d8e1684dfb2a3bde5526361e53c095f8250a8bc high confidence adjacent normal sample_accession: GSM6205121 sample_title: adjacent normal tissue-N1 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary sample type match: adjacent normal
sample_type normal tissue sample GSM6205123 Runtime Siftome inference GEO:sample:GSM6205123:3df2ea0a9c570ef6b34b8b1a4aa4a8a6f450c848e798b0318da3ce247a4b6827 high confidence adjacent normal sample_accession: GSM6205123 sample_title: adjacent normal tissue-N2 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary sample type match: adjacent normal
sample_type normal tissue sample GSM6205125 Runtime Siftome inference GEO:sample:GSM6205125:6afe29a166b5a0511fa21d10430f1f5683051ddbd9ce6ef42701202bedb5bcde high confidence adjacent normal sample_accession: GSM6205125 sample_title: adjacent normal tissue-N4 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary sample type match: adjacent normal
sample_type normal tissue sample GSM6205127 Runtime Siftome inference GEO:sample:GSM6205127:86207ea79a51963c1336ddab1f8a3f3174ded1289a530b5743653469cc6e6c2d high confidence adjacent normal sample_accession: GSM6205127 sample_title: adjacent normal tissue-N5 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary sample type match: adjacent normal
sample_type normal tissue sample GSM6205129 Runtime Siftome inference GEO:sample:GSM6205129:059140b8690484c606ab6399f3eecda783d51555d1b36944d647227e38129e1b high confidence adjacent normal sample_accession: GSM6205129 sample_title: adjacent normal tissue-N6 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary sample type match: adjacent normal
tissue colon dataset GSE205094 Runtime Siftome inference GEO:dataset:GSE205094:92eea0333ecaef4020e4e377af8bc6b482c3296f80ea3f3d79c0f33d7130f647 medium confidence colorectal dataset_accession: GSE205094 dataset_title: CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [miRNA-seq]... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6205120 Runtime Siftome inference GEO:sample:GSM6205120:28fea2c937ecee0deaee352a660ee6b347e0a4a4d15b715ab27a2ffa1f7a3fd4 medium confidence colorectal sample_accession: GSM6205120 sample_title: CRC-C1 (miRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: colorec... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6205121 Runtime Siftome inference GEO:sample:GSM6205121:55a691866124b21cedf93a645d8e1684dfb2a3bde5526361e53c095f8250a8bc medium confidence colorectal sample_accession: GSM6205121 sample_title: adjacent normal tissue-N1 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6205122 Runtime Siftome inference GEO:sample:GSM6205122:0c0c3bc3f7e93d41fa0cfaef3da8ed1cac8758b40ed87f2bf2bca95e0c6e88b2 medium confidence colorectal sample_accession: GSM6205122 sample_title: CRC-C2 (miRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: colorec... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6205123 Runtime Siftome inference GEO:sample:GSM6205123:3df2ea0a9c570ef6b34b8b1a4aa4a8a6f450c848e798b0318da3ce247a4b6827 medium confidence colorectal sample_accession: GSM6205123 sample_title: adjacent normal tissue-N2 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6205124 Runtime Siftome inference GEO:sample:GSM6205124:6aeb507a91fac511655d2b6cbb668f1ede257c22f9c85c06fdba84aa534b8325 medium confidence colorectal sample_accession: GSM6205124 sample_title: CRC-C4 (miRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: colorec... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6205125 Runtime Siftome inference GEO:sample:GSM6205125:6afe29a166b5a0511fa21d10430f1f5683051ddbd9ce6ef42701202bedb5bcde medium confidence colorectal sample_accession: GSM6205125 sample_title: adjacent normal tissue-N4 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6205126 Runtime Siftome inference GEO:sample:GSM6205126:8cd48a9a90caa4b514d678e8b1813f368b5fb1b1b61b76b371afbf2badceb07d medium confidence colorectal sample_accession: GSM6205126 sample_title: CRC-C5 (miRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: colorec... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6205127 Runtime Siftome inference GEO:sample:GSM6205127:86207ea79a51963c1336ddab1f8a3f3174ded1289a530b5743653469cc6e6c2d medium confidence colorectal sample_accession: GSM6205127 sample_title: adjacent normal tissue-N5 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6205128 Runtime Siftome inference GEO:sample:GSM6205128:3cad681123a8e220180808b9e9caf9e0b31025a6e669b1b51dc36a2170560ddb medium confidence colorectal sample_accession: GSM6205128 sample_title: CRC-C6 (miRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: colorec... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6205129 Runtime Siftome inference GEO:sample:GSM6205129:059140b8690484c606ab6399f3eecda783d51555d1b36944d647227e38129e1b medium confidence colorectal sample_accession: GSM6205129 sample_title: adjacent normal tissue-N6 (miRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal cance... controlled vocabulary controlled vocabulary tissue match: colorectal

Sample Group Preview

Possible case samples

Samples currently treated as the comparison case group.

5
  • GSM6205120 CRC-C1 (miRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6205122 CRC-C2 (miRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6205124 CRC-C4 (miRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6205126 CRC-C5 (miRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6205128 CRC-C6 (miRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)

Possible control samples

Samples currently treated as controls or baseline.

5
  • GSM6205121 adjacent normal tissue-N1 (miRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6205123 adjacent normal tissue-N2 (miRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6205125 adjacent normal tissue-N4 (miRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6205127 adjacent normal tissue-N5 (miRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6205129 adjacent normal tissue-N6 (miRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)

Unassigned samples

Samples with no explicit case or control marker.

0

No samples

Excluded samples

Samples excluded from grouping by hard exclusion rules.

0

No samples

Ambiguous samples

Samples that need manual review before trusting grouping.

0

No samples

Metadata Quality Components

Persisted metadata quality

100 pts
Clarity
100%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Tissue metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Detected Sample Groups

colorectal cancer

5 samples
  • GSM6205120 CRC-C1 (miRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6205122 CRC-C2 (miRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6205124 CRC-C4 (miRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6205126 CRC-C5 (miRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6205128 CRC-C6 (miRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)

normal tissue

5 samples
  • GSM6205121 adjacent normal tissue-N1 (miRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6205123 adjacent normal tissue-N2 (miRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6205125 adjacent normal tissue-N4 (miRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6205127 adjacent normal tissue-N5 (miRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6205129 adjacent normal tissue-N6 (miRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)

Score Breakdown

100%

relevance

  • Disease or condition metadata normalized.
  • Organism normalized.
  • Assay type normalized.
  • Tissue metadata normalized.
55%

comparison suitability

  • Case and control sample groups detected: colorectal cancer vs normal tissue.
  • No excluded sample type flags detected.
  • Matched tumor/normal design boosted for colorectal tumor-vs-normal tissue triage.
  • Patient tissue or biopsy specimens boosted for tissue comparison triage.
  • Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
  • Colorectal, colon, rectal, or CRC disease context boosted for tumor-vs-normal tissue ranking.
100%

metadata quality

  • Sample source clarity: All samples have source metadata and clear GSE/GSM accessions.
  • Group clarity: Rule-based grouping found both case and control samples.
  • Disease clarity: Disease or condition metadata normalized.
  • Tissue clarity: Tissue metadata normalized.
  • Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Replicate clarity: No pooled sample or technical replicate flags detected.
  • Data availability clarity: Dataset-level processed or raw data availability is explicit.
100%

data availability

  • Processed data available.
  • Raw data available.
50%

overall

  • Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.

Sample Links

10 samples

Review Audit Trail

0 decisions

No review decisions have been stored for this dataset.