Siftome Phase 3L

GSE205241

CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [circRNA-seq]

Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.
Sample grouping CSV Contrast CSV DESeq2 metadata CSV R handoff notes Handoff report Download instructions Open GEO dataset
Source
GEO
Search intent
Patient tissue tumor-vs-normal
Intent behavior
search-intent-behavior-v1
Submission date
2022-06-01
Last update
2022-06-04
Organization
Nanjing Medical University
Department
Department of Medical Genetics
Public date
2022-06-04
Experiment types
Non-coding RNA profiling by high throughput sequencing
Platforms
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Series type
SubSeries
SubSeries
Not available
BioProject
Not available
Supplementary files
TXT: GSE205241_count.txt.gz
Organism
Homo sapiens
Assay
bulk RNA-seq
Samples
12
Study design
Tumor vs matched normal
Specimen/source
Tissue
Scoring version
intent-aware-scoring-v15
Ranking batch
b69568dd1e4fe1b9ee2d880bf5495d748a7e4c5c11e4107f02528c3be0e76012
Ranking created
2026-06-05T20:20:27.088676Z
Warning version
intent-aware-warnings-v2

Current Intent Interpretation

Patient tissue tumor-vs-normal

Expectations

Organism
Homo sapiens
Assay
bulk RNA-seq
Specimen/source
patient tissue or biopsy
Controls
matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control

Rules

Default filters
Human only; Bulk RNA-seq only; Tumor-normal only; Tissue or biopsy only; Hide biofluid/model systems
Warning rules
missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
Score caps
non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
Downgraded contexts
microarray unless explicitly enabled, biofluid-only datasets, cell-line datasets, organoid datasets, xenograft or PDX datasets, non-colorectal disease contexts, or treatment-only experiments

Study Classification

Tumor vs matched normal Tissue

Analysis Readiness

Review before analysis
97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

  • Secondary RNA assay context should be analyzed separately from ordinary bulk RNA-seq.

Next Steps

  • Review blockers and update sample grouping or dataset selection before analysis.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Still scan the grouping table for biology-specific ambiguity.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source links preserved

Ready

The dataset and sample accessions can be linked back to GEO.

Keep GEO dataset and sample links with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

  • Analysis readiness has blockers that must be resolved before DE.
  • Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Patient tissue tumor-vs-normal
Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.

Score Components

  • relevance 100% Disease or condition metadata normalized. Organism normalized. Assay type normalized. Tissue metadata normalized.
  • comparison suitability 55% Case and control sample groups detected: colorectal cancer vs normal tissue. No excluded sample type flags detected. Matched tumor/normal design boosted for colorectal tumor-vs-normal tissue triage. Patient tissue or biopsy specimens boosted for tissue comparison triage. Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking. Colorectal, colon, rectal, or CRC disease context boosted for tumor-vs-normal tissue ranking.
  • metadata quality 100% Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Tissue metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.
  • data availability 100% Processed data available. Raw data available.
  • overall 50% Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability. Overall score capped because comparison suitability is weak for the selected search intent. Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.

Derived Classifications

  • Organism Homo sapiens Organism remains rule-derived: Homo sapiens.
  • Assay bulk RNA-seq Assay remains rule-derived: bulk RNA-seq.
  • Study design Tumor vs matched normal Study design remains rule-derived: Tumor vs matched normal.
  • Specimen/source Tissue Specimen/source remains rule-derived: Tissue.
  • Likely case group colorectal cancer 6 samples
  • Likely control group normal tissue 6 samples

Warnings

  • SECONDARY_ASSAY_CONTEXT warning Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.

Intent Interpretation

  • Active intent Patient tissue tumor-vs-normal Ranks human colorectal tissue or biopsy cohorts where tumor samples can be compared with normal controls.
  • Organism expectation Homo sapiens Dataset organism is interpreted as Homo sapiens.
  • Assay expectation bulk RNA-seq Dataset assay is interpreted as bulk RNA-seq.
  • Specimen assumption patient tissue or biopsy Derived specimen/source is Tissue.
  • Control-group assumption matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control Derived study design is Tumor vs matched normal; likely groups are colorectal cancer vs normal tissue.
  • Score caps Applied when matching conditions are present non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
  • Warning rules 1 active warning missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
  • Downgrade or exclusion reason 1 warning require review. Derived from current-intent ranking reasons and warnings.

Applied Review Decisions

No active review decisions affect this ranking.

Ranking Facts

  • Recommendation Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.
  • Supporting fact Tumor vs matched normal · Tissue · suitability 55%. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized for patient tissue tumor-vs-normal triage. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized assay: bulk RNA-seq is the active assay expectation. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized disease context: colorectal, colon, rectal, or CRC metadata detected. Contributed to match or upgrade evidence.
  • Supporting fact Processed data is available for downstream review. Contributed to match or upgrade evidence.
  • Supporting fact 1 warning require review. Contributed to match or upgrade evidence.
  • Caution fact Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected. Contributed to downgrade or manual-review evidence.
  • Caution fact Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because comparison suitability is weak for the selected search intent. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq. Contributed to downgrade or manual-review evidence.
  • Caution fact Comparison suitability score is below the Phase 1 recommended threshold. Contributed to downgrade or manual-review evidence.

Manual Corrections

0 active

Source Evidence

4 sources

GEO

Primary source

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Dataset accession
GSE205241
Sample records
12 GSM samples
  • GEO has priority for original metadata under the Phase 3J source rules.
  • Processed data: available.
  • Raw data: available.
  • No external source conflict is present in the current runtime data.

recount3

Not imported

Planned trusted source for processed count availability.

GEO accession
GSE205241
  • No recount3 project identifier has been imported for this dataset.
  • Once imported, recount3 has priority for processed count availability.
  • The recount3 source filter excludes this dataset until that linkage exists.
No recount3 sync data available.

Expression Atlas

Not imported

Planned source for curated expression experiment links.

GEO accession
GSE205241
  • No Expression Atlas experiment identifier has been imported for this dataset.
  • Once imported, Expression Atlas has priority for curated expression experiment links.
  • The Expression Atlas source filter excludes this dataset until that linkage exists.
No Expression Atlas sync data available.

PubMed

Unavailable

Publication context when PubMed identifiers are already known.

GEO accession
GSE205241
  • No PubMed identifier is present in the current runtime metadata.
  • No live PubMed search is performed from the dataset detail page.
No publication identifier imported.

Dataset Feedback

0 stored

Original GEO Metadata

dataset_accession: GSE205241
dataset_title: CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [circRNA-seq]
organism: Homo sapiens
assay_type: bulk RNA-seq
processed_data_available: true
raw_data_available: true
submission_date: 2022-06-01
last_update_date: 2022-06-04
organization_name: Nanjing Medical University
department: Department of Medical Genetics
public_date: 2022-06-04
experiment_types: Non-coding RNA profiling by high throughput sequencing
platforms: GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
sub_series: Not available
bioproject: Not available
supplementary_files: TXT: GSE205241_count.txt.gz
series_type: SubSeries

Why It Matched

  • Tumor vs matched normal · Tissue · suitability 55%.
  • Prioritized for patient tissue tumor-vs-normal triage.
  • Prioritized assay: bulk RNA-seq is the active assay expectation.
  • Prioritized disease context: colorectal, colon, rectal, or CRC metadata detected.
  • Processed data is available for downstream review.
  • 1 warning require review.

Why It May Not Be Suitable

  • Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.
  • Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
  • Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Warnings

  • warning SECONDARY_ASSAY_CONTEXT Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.

Normalized Fields

40 fields
Field Value Source Origin Confidence Evidence Reason
assay_type bulk RNA-seq dataset GSE205241 Runtime Siftome inference GEO:dataset:GSE205241:aa915cf965fdcbe6d65fd6650862f404bf720ebe60ed5513e2da38ba06b34e3d high confidence bulk rna-seq dataset_accession: GSE205241 dataset_title: CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [circRNA-se... keyword match keyword match: bulk rna-seq
disease colorectal cancer dataset GSE205241 Runtime Siftome inference GEO:dataset:GSE205241:aa915cf965fdcbe6d65fd6650862f404bf720ebe60ed5513e2da38ba06b34e3d high confidence colorectal cancer dataset_accession: GSE205241 dataset_title: CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [circRNA-se... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208953 Runtime Siftome inference GEO:sample:GSM6208953:6df90bdd163c099a30b2353ca0e46529cc5274b6282bc32a67f0c59bde4b377e high confidence colorectal cancer sample_accession: GSM6208953 sample_title: CRC-N6 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208954 Runtime Siftome inference GEO:sample:GSM6208954:7875f6f1bbddbb5456a4e8680c2d03cb966a08bd3707c516594b7332e9f59939 high confidence colorectal cancer sample_accession: GSM6208954 sample_title: adjacent normal tissue-C6 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208955 Runtime Siftome inference GEO:sample:GSM6208955:c6f27361aa59441ef3e4a843ceb9061d735d9b4ddb33bc6b48f6f6ecdb8c3113 high confidence colorectal cancer sample_accession: GSM6208955 sample_title: CRC-N5 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208956 Runtime Siftome inference GEO:sample:GSM6208956:aa273197689dd0d997d7f6e1f999d5a2e9f86cfac2419131c68f4c7db24e6b55 high confidence colorectal cancer sample_accession: GSM6208956 sample_title: adjacent normal tissue-C5 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208957 Runtime Siftome inference GEO:sample:GSM6208957:b8d6ed628246f0c56d7450d2e25e73be765f63bfb6ebecd91154ffe8d47db077 high confidence colorectal cancer sample_accession: GSM6208957 sample_title: CRC-N4 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208958 Runtime Siftome inference GEO:sample:GSM6208958:70774ece5b619d6439aa180cc47026c800294898b6283adf37a78c7d0b7f25f7 high confidence colorectal cancer sample_accession: GSM6208958 sample_title: adjacent normal tissue-C4 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208959 Runtime Siftome inference GEO:sample:GSM6208959:f131d264f732c4a3639cef9298c61fff585b5547bbe751f118cc6398e919fcb9 high confidence colorectal cancer sample_accession: GSM6208959 sample_title: CRC-N2 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208960 Runtime Siftome inference GEO:sample:GSM6208960:1a7564521996407cb986e515d76e6e98559cf272a7173801eca7b3dc9a74b002 high confidence colorectal cancer sample_accession: GSM6208960 sample_title: adjacent normal tissue-C2 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208961 Runtime Siftome inference GEO:sample:GSM6208961:c1d9f158bd858afb6fe44c266d9171d91e57a639696fc5f9864857c913c363a4 high confidence colorectal cancer sample_accession: GSM6208961 sample_title: CRC-N1 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208962 Runtime Siftome inference GEO:sample:GSM6208962:e3157ec95df2c5df827968121e8a697c4bb5f106893a6184f6ac51fd8b2fee79 high confidence colorectal cancer sample_accession: GSM6208962 sample_title: adjacent normal tissue-C1 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208963 Runtime Siftome inference GEO:sample:GSM6208963:9519431a0baf04731c75fb2d89d79a0239f3306919dfc0f5fe836a8e7bff443d high confidence colorectal cancer sample_accession: GSM6208963 sample_title: CRC-N3 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary disease match: colorectal cancer
disease colorectal cancer sample GSM6208964 Runtime Siftome inference GEO:sample:GSM6208964:bf1676a0fb13aa0e6d06d8b0d67fadfcd73b20573af756ab28b949a16dbb0a9c high confidence colorectal cancer sample_accession: GSM6208964 sample_title: adjacent normal tissue-C3 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary disease match: colorectal cancer
normal_tissue_type adjacent normal sample GSM6208954 Runtime Siftome inference GEO:sample:GSM6208954:7875f6f1bbddbb5456a4e8680c2d03cb966a08bd3707c516594b7332e9f59939 high confidence adjacent normal sample_accession: GSM6208954 sample_title: adjacent normal tissue-C6 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
normal_tissue_type adjacent normal sample GSM6208956 Runtime Siftome inference GEO:sample:GSM6208956:aa273197689dd0d997d7f6e1f999d5a2e9f86cfac2419131c68f4c7db24e6b55 high confidence adjacent normal sample_accession: GSM6208956 sample_title: adjacent normal tissue-C5 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
normal_tissue_type adjacent normal sample GSM6208958 Runtime Siftome inference GEO:sample:GSM6208958:70774ece5b619d6439aa180cc47026c800294898b6283adf37a78c7d0b7f25f7 high confidence adjacent normal sample_accession: GSM6208958 sample_title: adjacent normal tissue-C4 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
normal_tissue_type adjacent normal sample GSM6208960 Runtime Siftome inference GEO:sample:GSM6208960:1a7564521996407cb986e515d76e6e98559cf272a7173801eca7b3dc9a74b002 high confidence adjacent normal sample_accession: GSM6208960 sample_title: adjacent normal tissue-C2 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
normal_tissue_type adjacent normal sample GSM6208962 Runtime Siftome inference GEO:sample:GSM6208962:e3157ec95df2c5df827968121e8a697c4bb5f106893a6184f6ac51fd8b2fee79 high confidence adjacent normal sample_accession: GSM6208962 sample_title: adjacent normal tissue-C1 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
normal_tissue_type adjacent normal sample GSM6208964 Runtime Siftome inference GEO:sample:GSM6208964:bf1676a0fb13aa0e6d06d8b0d67fadfcd73b20573af756ab28b949a16dbb0a9c high confidence adjacent normal sample_accession: GSM6208964 sample_title: adjacent normal tissue-C3 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary normal tissue type match: adjacent normal
organism Homo sapiens dataset GSE205241 Runtime Siftome inference GEO:dataset:GSE205241:aa915cf965fdcbe6d65fd6650862f404bf720ebe60ed5513e2da38ba06b34e3d high confidence homo sapiens dataset_accession: GSE205241 dataset_title: CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [circRNA-se... keyword match keyword match: homo sapiens
sample_type normal tissue sample GSM6208954 Runtime Siftome inference GEO:sample:GSM6208954:7875f6f1bbddbb5456a4e8680c2d03cb966a08bd3707c516594b7332e9f59939 high confidence adjacent normal sample_accession: GSM6208954 sample_title: adjacent normal tissue-C6 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary sample type match: adjacent normal
sample_type normal tissue sample GSM6208956 Runtime Siftome inference GEO:sample:GSM6208956:aa273197689dd0d997d7f6e1f999d5a2e9f86cfac2419131c68f4c7db24e6b55 high confidence adjacent normal sample_accession: GSM6208956 sample_title: adjacent normal tissue-C5 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary sample type match: adjacent normal
sample_type normal tissue sample GSM6208958 Runtime Siftome inference GEO:sample:GSM6208958:70774ece5b619d6439aa180cc47026c800294898b6283adf37a78c7d0b7f25f7 high confidence adjacent normal sample_accession: GSM6208958 sample_title: adjacent normal tissue-C4 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary sample type match: adjacent normal
sample_type normal tissue sample GSM6208960 Runtime Siftome inference GEO:sample:GSM6208960:1a7564521996407cb986e515d76e6e98559cf272a7173801eca7b3dc9a74b002 high confidence adjacent normal sample_accession: GSM6208960 sample_title: adjacent normal tissue-C2 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary sample type match: adjacent normal
sample_type normal tissue sample GSM6208962 Runtime Siftome inference GEO:sample:GSM6208962:e3157ec95df2c5df827968121e8a697c4bb5f106893a6184f6ac51fd8b2fee79 high confidence adjacent normal sample_accession: GSM6208962 sample_title: adjacent normal tissue-C1 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary sample type match: adjacent normal
sample_type normal tissue sample GSM6208964 Runtime Siftome inference GEO:sample:GSM6208964:bf1676a0fb13aa0e6d06d8b0d67fadfcd73b20573af756ab28b949a16dbb0a9c high confidence adjacent normal sample_accession: GSM6208964 sample_title: adjacent normal tissue-C3 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary sample type match: adjacent normal
tissue colon dataset GSE205241 Runtime Siftome inference GEO:dataset:GSE205241:aa915cf965fdcbe6d65fd6650862f404bf720ebe60ed5513e2da38ba06b34e3d medium confidence colorectal dataset_accession: GSE205241 dataset_title: CircEZH2 miR-133b IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A modified CREB1 mRNA [circRNA-se... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208953 Runtime Siftome inference GEO:sample:GSM6208953:6df90bdd163c099a30b2353ca0e46529cc5274b6282bc32a67f0c59bde4b377e medium confidence colorectal sample_accession: GSM6208953 sample_title: CRC-N6 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208954 Runtime Siftome inference GEO:sample:GSM6208954:7875f6f1bbddbb5456a4e8680c2d03cb966a08bd3707c516594b7332e9f59939 medium confidence colorectal sample_accession: GSM6208954 sample_title: adjacent normal tissue-C6 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208955 Runtime Siftome inference GEO:sample:GSM6208955:c6f27361aa59441ef3e4a843ceb9061d735d9b4ddb33bc6b48f6f6ecdb8c3113 medium confidence colorectal sample_accession: GSM6208955 sample_title: CRC-N5 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208956 Runtime Siftome inference GEO:sample:GSM6208956:aa273197689dd0d997d7f6e1f999d5a2e9f86cfac2419131c68f4c7db24e6b55 medium confidence colorectal sample_accession: GSM6208956 sample_title: adjacent normal tissue-C5 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208957 Runtime Siftome inference GEO:sample:GSM6208957:b8d6ed628246f0c56d7450d2e25e73be765f63bfb6ebecd91154ffe8d47db077 medium confidence colorectal sample_accession: GSM6208957 sample_title: CRC-N4 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208958 Runtime Siftome inference GEO:sample:GSM6208958:70774ece5b619d6439aa180cc47026c800294898b6283adf37a78c7d0b7f25f7 medium confidence colorectal sample_accession: GSM6208958 sample_title: adjacent normal tissue-C4 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208959 Runtime Siftome inference GEO:sample:GSM6208959:f131d264f732c4a3639cef9298c61fff585b5547bbe751f118cc6398e919fcb9 medium confidence colorectal sample_accession: GSM6208959 sample_title: CRC-N2 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208960 Runtime Siftome inference GEO:sample:GSM6208960:1a7564521996407cb986e515d76e6e98559cf272a7173801eca7b3dc9a74b002 medium confidence colorectal sample_accession: GSM6208960 sample_title: adjacent normal tissue-C2 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208961 Runtime Siftome inference GEO:sample:GSM6208961:c1d9f158bd858afb6fe44c266d9171d91e57a639696fc5f9864857c913c363a4 medium confidence colorectal sample_accession: GSM6208961 sample_title: CRC-N1 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208962 Runtime Siftome inference GEO:sample:GSM6208962:e3157ec95df2c5df827968121e8a697c4bb5f106893a6184f6ac51fd8b2fee79 medium confidence colorectal sample_accession: GSM6208962 sample_title: adjacent normal tissue-C1 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208963 Runtime Siftome inference GEO:sample:GSM6208963:9519431a0baf04731c75fb2d89d79a0239f3306919dfc0f5fe836a8e7bff443d medium confidence colorectal sample_accession: GSM6208963 sample_title: CRC-N3 (circRNA-seq) source_name: colorectal cancer (intestine) characteristics: disease state: colorectal cancer (CRC); tissue: color... controlled vocabulary controlled vocabulary tissue match: colorectal
tissue colon sample GSM6208964 Runtime Siftome inference GEO:sample:GSM6208964:bf1676a0fb13aa0e6d06d8b0d67fadfcd73b20573af756ab28b949a16dbb0a9c medium confidence colorectal sample_accession: GSM6208964 sample_title: adjacent normal tissue-C3 (circRNA-seq) source_name: adjacent normal tissue (intestine) characteristics: disease state: colorectal can... controlled vocabulary controlled vocabulary tissue match: colorectal

Sample Group Preview

Possible case samples

Samples currently treated as the comparison case group.

6
  • GSM6208953 CRC-N6 (circRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6208955 CRC-N5 (circRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6208957 CRC-N4 (circRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6208959 CRC-N2 (circRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6208961 CRC-N1 (circRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6208963 CRC-N3 (circRNA-seq) colorectal cancer Case marker detected. colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)

Possible control samples

Samples currently treated as controls or baseline.

6
  • GSM6208954 adjacent normal tissue-C6 (circRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6208956 adjacent normal tissue-C5 (circRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6208958 adjacent normal tissue-C4 (circRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6208960 adjacent normal tissue-C2 (circRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6208962 adjacent normal tissue-C1 (circRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6208964 adjacent normal tissue-C3 (circRNA-seq) normal tissue Control marker detected. adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)

Unassigned samples

Samples with no explicit case or control marker.

0

No samples

Excluded samples

Samples excluded from grouping by hard exclusion rules.

0

No samples

Ambiguous samples

Samples that need manual review before trusting grouping.

0

No samples

Metadata Quality Components

Persisted metadata quality

100 pts
Clarity
100%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Tissue metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Detected Sample Groups

colorectal cancer

6 samples
  • GSM6208953 CRC-N6 (circRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6208955 CRC-N5 (circRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6208957 CRC-N4 (circRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6208959 CRC-N2 (circRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6208961 CRC-N1 (circRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)
  • GSM6208963 CRC-N3 (circRNA-seq) colorectal cancer (intestine) disease state: colorectal cancer (CRC); tissue: colorectal cancer (intestine)

normal tissue

6 samples
  • GSM6208954 adjacent normal tissue-C6 (circRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6208956 adjacent normal tissue-C5 (circRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6208958 adjacent normal tissue-C4 (circRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6208960 adjacent normal tissue-C2 (circRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6208962 adjacent normal tissue-C1 (circRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)
  • GSM6208964 adjacent normal tissue-C3 (circRNA-seq) adjacent normal tissue (intestine) disease state: colorectal cancer (CRC); tissue: adjacent normal tissue (intestine)

Score Breakdown

100%

relevance

  • Disease or condition metadata normalized.
  • Organism normalized.
  • Assay type normalized.
  • Tissue metadata normalized.
55%

comparison suitability

  • Case and control sample groups detected: colorectal cancer vs normal tissue.
  • No excluded sample type flags detected.
  • Matched tumor/normal design boosted for colorectal tumor-vs-normal tissue triage.
  • Patient tissue or biopsy specimens boosted for tissue comparison triage.
  • Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
  • Colorectal, colon, rectal, or CRC disease context boosted for tumor-vs-normal tissue ranking.
100%

metadata quality

  • Sample source clarity: All samples have source metadata and clear GSE/GSM accessions.
  • Group clarity: Rule-based grouping found both case and control samples.
  • Disease clarity: Disease or condition metadata normalized.
  • Tissue clarity: Tissue metadata normalized.
  • Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Replicate clarity: No pooled sample or technical replicate flags detected.
  • Data availability clarity: Dataset-level processed or raw data availability is explicit.
100%

data availability

  • Processed data available.
  • Raw data available.
50%

overall

  • Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.

Sample Links

12 samples

Review Audit Trail

0 decisions

No review decisions have been stored for this dataset.