Siftome Phase 3L

GSE206448

RNA-Seq analysis for giant cell tumour of the bone

Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.
Sample grouping CSV Contrast CSV DESeq2 metadata CSV R handoff notes Handoff report Download instructions Open GEO dataset
Source
GEO
Search intent
Patient tissue tumor-vs-normal
Intent behavior
search-intent-behavior-v1
Submission date
2022-06-20
Last update
2022-06-24
Organization
shanghai chagnzheng hospital
Department
Not available
Public date
2022-06-24
Experiment types
Expression profiling by high throughput sequencing
Platforms
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Series type
Series
SubSeries
Not available
BioProject
PRJNA850942
Supplementary files
TXT: GSE206448_All.counts_circRNA.txt.gz; TXT: GSE206448_All.counts_mRNA_lncRNA.txt.gz
Organism
Homo sapiens
Assay
bulk RNA-seq
Samples
10
Study design
Tumor vs unmatched normal
Specimen/source
Tissue
Scoring version
intent-aware-scoring-v15
Ranking batch
b69568dd1e4fe1b9ee2d880bf5495d748a7e4c5c11e4107f02528c3be0e76012
Ranking created
2026-06-05T20:20:27.088676Z
Warning version
intent-aware-warnings-v2

Current Intent Interpretation

Patient tissue tumor-vs-normal

Expectations

Organism
Homo sapiens
Assay
bulk RNA-seq
Specimen/source
patient tissue or biopsy
Controls
matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control

Rules

Default filters
Human only; Bulk RNA-seq only; Tumor-normal only; Tissue or biopsy only; Hide biofluid/model systems
Warning rules
missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
Score caps
non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
Downgraded contexts
microarray unless explicitly enabled, biofluid-only datasets, cell-line datasets, organoid datasets, xenograft or PDX datasets, non-colorectal disease contexts, or treatment-only experiments

Study Classification

Tumor vs unmatched normal Tissue

Analysis Readiness

Review before analysis
94% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

7/10 pts

Metadata quality is usable, but still deserves review.

Blockers

  • Secondary RNA assay context should be analyzed separately from ordinary bulk RNA-seq.

Next Steps

  • Review blockers and update sample grouping or dataset selection before analysis.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Still scan the grouping table for biology-specific ambiguity.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source links preserved

Ready

The dataset and sample accessions can be linked back to GEO.

Keep GEO dataset and sample links with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

  • Analysis readiness has blockers that must be resolved before DE.
  • Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Patient tissue tumor-vs-normal
Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.

Score Components

  • relevance 50% Organism normalized. Assay type normalized.
  • comparison suitability 5% Tumor and normal sample groups detected. No excluded sample type flags detected. Tumor/normal design boosted for colorectal tumor-vs-normal tissue triage. Patient tissue or biopsy specimens boosted for tissue comparison triage. Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking.
  • metadata quality 70% Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata was not normalized. Tissue clarity: Tissue metadata was not normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.
  • data availability 100% Processed data available. Raw data available.
  • overall 45% Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability. Overall score capped because comparison suitability is weak for the selected search intent. Overall score capped because colorectal/CRC disease context is not explicit.

Derived Classifications

  • Organism Homo sapiens Organism remains rule-derived: Homo sapiens.
  • Assay bulk RNA-seq Assay remains rule-derived: bulk RNA-seq.
  • Study design Tumor vs unmatched normal Study design remains rule-derived: Tumor vs unmatched normal.
  • Specimen/source Tissue Specimen/source remains rule-derived: Tissue.
  • Likely case group tumor sample 5 samples
  • Likely control group normal tissue 5 samples

Warnings

  • SECONDARY_ASSAY_CONTEXT warning Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.
  • DISEASE_LABEL_UNCLEAR warning Disease or condition label could not be normalized.
  • TISSUE_TYPE_MISSING warning Tissue or cell type could not be normalized.

Intent Interpretation

  • Active intent Patient tissue tumor-vs-normal Ranks human colorectal tissue or biopsy cohorts where tumor samples can be compared with normal controls.
  • Organism expectation Homo sapiens Dataset organism is interpreted as Homo sapiens.
  • Assay expectation bulk RNA-seq Dataset assay is interpreted as bulk RNA-seq.
  • Specimen assumption patient tissue or biopsy Derived specimen/source is Tissue.
  • Control-group assumption matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control Derived study design is Tumor vs unmatched normal; likely groups are tumor sample vs normal tissue.
  • Score caps Applied when matching conditions are present non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
  • Warning rules 3 active warnings missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
  • Downgrade or exclusion reason Downgraded disease context: colorectal/GI relevance is unclear. Derived from current-intent ranking reasons and warnings.

Applied Review Decisions

No active review decisions affect this ranking.

Ranking Facts

  • Recommendation Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.
  • Supporting fact Tumor vs unmatched normal · Tissue · suitability 5%. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized assay: bulk RNA-seq is the active assay expectation. Contributed to match or upgrade evidence.
  • Supporting fact Downgraded disease context: colorectal/GI relevance is unclear. Contributed to match or upgrade evidence.
  • Supporting fact Processed data is available for downstream review. Contributed to match or upgrade evidence.
  • Supporting fact 3 warnings require review. Contributed to match or upgrade evidence.
  • Caution fact Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected. Contributed to downgrade or manual-review evidence.
  • Caution fact Disease or condition label could not be normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Tissue or cell type could not be normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Disease clarity: Disease or condition metadata was not normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Tissue clarity: Tissue metadata was not normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because comparison suitability is weak for the selected search intent. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because colorectal/CRC disease context is not explicit. Contributed to downgrade or manual-review evidence.
  • Caution fact Downgraded disease context: colorectal/GI relevance is unclear. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Downgraded disease context: colorectal/GI relevance is unclear. Contributed to downgrade or manual-review evidence.
  • Caution fact Comparison suitability score is below the Phase 1 recommended threshold. Contributed to downgrade or manual-review evidence.

Manual Corrections

0 active

Source Evidence

4 sources

GEO

Primary source

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Dataset accession
GSE206448
Sample records
10 GSM samples
  • GEO has priority for original metadata under the Phase 3J source rules.
  • Processed data: available.
  • Raw data: available.
  • No external source conflict is present in the current runtime data.

recount3

Not imported

Planned trusted source for processed count availability.

GEO accession
GSE206448
  • No recount3 project identifier has been imported for this dataset.
  • Once imported, recount3 has priority for processed count availability.
  • The recount3 source filter excludes this dataset until that linkage exists.
No recount3 sync data available.

Expression Atlas

Not imported

Planned source for curated expression experiment links.

GEO accession
GSE206448
  • No Expression Atlas experiment identifier has been imported for this dataset.
  • Once imported, Expression Atlas has priority for curated expression experiment links.
  • The Expression Atlas source filter excludes this dataset until that linkage exists.
No Expression Atlas sync data available.

PubMed

Unavailable

Publication context when PubMed identifiers are already known.

GEO accession
GSE206448
  • No PubMed identifier is present in the current runtime metadata.
  • No live PubMed search is performed from the dataset detail page.
No publication identifier imported.

Dataset Feedback

0 stored

Original GEO Metadata

dataset_accession: GSE206448
dataset_title: RNA-Seq analysis for giant cell tumour of the bone
organism: Homo sapiens
assay_type: bulk RNA-seq
processed_data_available: true
raw_data_available: true
submission_date: 2022-06-20
last_update_date: 2022-06-24
organization_name: shanghai chagnzheng hospital
department: Not available
public_date: 2022-06-24
experiment_types: Expression profiling by high throughput sequencing
platforms: GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
sub_series: Not available
bioproject: PRJNA850942
supplementary_files: TXT: GSE206448_All.counts_circRNA.txt.gz; TXT: GSE206448_All.counts_mRNA_lncRNA.txt.gz
series_type: Series

Why It Matched

  • Tumor vs unmatched normal · Tissue · suitability 5%.
  • Prioritized assay: bulk RNA-seq is the active assay expectation.
  • Downgraded disease context: colorectal/GI relevance is unclear.
  • Processed data is available for downstream review.
  • 3 warnings require review.

Why It May Not Be Suitable

  • Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.
  • Disease or condition label could not be normalized.
  • Tissue or cell type could not be normalized.
  • Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking.
  • Missing or unclear metadata: Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking.
  • Missing or unclear metadata: Disease clarity: Disease or condition metadata was not normalized.
  • Missing or unclear metadata: Tissue clarity: Tissue metadata was not normalized.
  • Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because colorectal/CRC disease context is not explicit.
  • Downgraded disease context: colorectal/GI relevance is unclear.
  • Missing or unclear metadata: Downgraded disease context: colorectal/GI relevance is unclear.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Warnings

  • warning SECONDARY_ASSAY_CONTEXT Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.
  • warning DISEASE_LABEL_UNCLEAR Disease or condition label could not be normalized.
  • warning TISSUE_TYPE_MISSING Tissue or cell type could not be normalized.

Normalized Fields

17 fields
Field Value Source Origin Confidence Evidence Reason
assay_type bulk RNA-seq dataset GSE206448 Runtime Siftome inference GEO:dataset:GSE206448:a6c24e41f343c24d1c6b93eb921ddf3a4e07d985f053eaf0c0aa61127bc62c8a high confidence bulk rna-seq dataset_accession: GSE206448 dataset_title: RNA-Seq analysis for giant cell tumour of the bone organism: Homo sapiens assay_type: bulk RNA-seq processed_data_available: true raw... keyword match keyword match: bulk rna-seq
organism Homo sapiens dataset GSE206448 Runtime Siftome inference GEO:dataset:GSE206448:a6c24e41f343c24d1c6b93eb921ddf3a4e07d985f053eaf0c0aa61127bc62c8a high confidence homo sapiens dataset_accession: GSE206448 dataset_title: RNA-Seq analysis for giant cell tumour of the bone organism: Homo sapiens assay_type: bulk RNA-seq processed_data_available: true raw... keyword match keyword match: homo sapiens
sample_type normal tissue sample GSM6254240 Runtime Siftome inference GEO:sample:GSM6254240:2501c5829ad266a878b97343a88cbb16febc4993db9b7c5d0a294caac25cc744 low confidence normal sample_accession: GSM6254240 sample_title: A-1 source_name: bone characteristics: tissue: bone; age: 34; Sex: female; tumor stage: normal tissue A-1 controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6254240 Runtime Siftome inference GEO:sample:GSM6254240:2501c5829ad266a878b97343a88cbb16febc4993db9b7c5d0a294caac25cc744 low confidence tumor sample_accession: GSM6254240 sample_title: A-1 source_name: bone characteristics: tissue: bone; age: 34; Sex: female; tumor stage: normal tissue A-1 controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM6254241 Runtime Siftome inference GEO:sample:GSM6254241:6a0148df2500650c992fa5efb6737a35cea101a15b627b8422e60c911c24c385 low confidence normal sample_accession: GSM6254241 sample_title: A-2 source_name: bone characteristics: tissue: bone; age: 40; Sex: male; tumor stage: normal tissue A-2 controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6254241 Runtime Siftome inference GEO:sample:GSM6254241:6a0148df2500650c992fa5efb6737a35cea101a15b627b8422e60c911c24c385 low confidence tumor sample_accession: GSM6254241 sample_title: A-2 source_name: bone characteristics: tissue: bone; age: 40; Sex: male; tumor stage: normal tissue A-2 controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM6254242 Runtime Siftome inference GEO:sample:GSM6254242:d77d23c084faf194065fb90f903d6fda7d33a73c19b5a6a473837cf3c59c464f low confidence normal sample_accession: GSM6254242 sample_title: A-3 source_name: bone characteristics: tissue: bone; age: 50; Sex: male; tumor stage: normal tissue A-3 controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6254242 Runtime Siftome inference GEO:sample:GSM6254242:d77d23c084faf194065fb90f903d6fda7d33a73c19b5a6a473837cf3c59c464f low confidence tumor sample_accession: GSM6254242 sample_title: A-3 source_name: bone characteristics: tissue: bone; age: 50; Sex: male; tumor stage: normal tissue A-3 controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM6254243 Runtime Siftome inference GEO:sample:GSM6254243:5eee95c073753f0933b52d2d87c7613fe9ff0355fdf928b199a6f662787fa678 low confidence normal sample_accession: GSM6254243 sample_title: A-4 source_name: bone characteristics: tissue: bone; age: 36; Sex: female; tumor stage: normal tissue A-4 controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6254243 Runtime Siftome inference GEO:sample:GSM6254243:5eee95c073753f0933b52d2d87c7613fe9ff0355fdf928b199a6f662787fa678 low confidence tumor sample_accession: GSM6254243 sample_title: A-4 source_name: bone characteristics: tissue: bone; age: 36; Sex: female; tumor stage: normal tissue A-4 controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM6254244 Runtime Siftome inference GEO:sample:GSM6254244:9d8a8bf155e8657930204d2c14394513a55f871f7c84151a80f208eb4a9da883 low confidence normal sample_accession: GSM6254244 sample_title: A-5 source_name: bone characteristics: tissue: bone; age: 45; Sex: male; tumor stage: normal tissue A-5 controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6254244 Runtime Siftome inference GEO:sample:GSM6254244:9d8a8bf155e8657930204d2c14394513a55f871f7c84151a80f208eb4a9da883 low confidence tumor sample_accession: GSM6254244 sample_title: A-5 source_name: bone characteristics: tissue: bone; age: 45; Sex: male; tumor stage: normal tissue A-5 controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6254245 Runtime Siftome inference GEO:sample:GSM6254245:ac834afe3405604d53eae19d2b54968ed32fa95baa87ac411fc09b0f67facc35 low confidence tumor sample_accession: GSM6254245 sample_title: T-1 source_name: bone characteristics: tissue: bone; age: 34; Sex: female; tumor stage: stage I T-1 controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6254246 Runtime Siftome inference GEO:sample:GSM6254246:c4ae5dd8dcf124748610601c0f2890113ba24345017a2243252f0c109f7195d3 low confidence tumor sample_accession: GSM6254246 sample_title: T-2 source_name: bone characteristics: tissue: bone; age: 40; Sex: male; tumor stage: stage I T-2 controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6254247 Runtime Siftome inference GEO:sample:GSM6254247:db1f7b965f0c8676ca0c34024650d2f0996bf9021a065c43542238b6dd510b97 low confidence tumor sample_accession: GSM6254247 sample_title: T-3 source_name: bone characteristics: tissue: bone; age: 50; Sex: male; tumor stage: stage II T-3 controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6254248 Runtime Siftome inference GEO:sample:GSM6254248:20e1f6dc199925cf74f58462b0ac5140d5d1b580bc182abb16744dbafe40fe7e low confidence tumor sample_accession: GSM6254248 sample_title: T-4 source_name: bone characteristics: tissue: bone; age: 36; Sex: female; tumor stage: stage I T-4 controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6254249 Runtime Siftome inference GEO:sample:GSM6254249:49af8585eeeef8c63e6b5443b5a83e585307d17d5f24e558a995642fdc58f2dc low confidence tumor sample_accession: GSM6254249 sample_title: T-5 source_name: bone characteristics: tissue: bone; age: 45; Sex: male; tumor stage: stage II T-5 controlled vocabulary controlled vocabulary sample type match: tumor

Sample Group Preview

Possible case samples

Samples currently treated as the comparison case group.

5
  • GSM6254245 T-1 tumor sample Case marker detected. bone tissue: bone; age: 34; Sex: female; tumor stage: stage I
  • GSM6254246 T-2 tumor sample Case marker detected. bone tissue: bone; age: 40; Sex: male; tumor stage: stage I
  • GSM6254247 T-3 tumor sample Case marker detected. bone tissue: bone; age: 50; Sex: male; tumor stage: stage II
  • GSM6254248 T-4 tumor sample Case marker detected. bone tissue: bone; age: 36; Sex: female; tumor stage: stage I
  • GSM6254249 T-5 tumor sample Case marker detected. bone tissue: bone; age: 45; Sex: male; tumor stage: stage II

Possible control samples

Samples currently treated as controls or baseline.

5
  • GSM6254240 A-1 normal tissue Control marker detected. bone tissue: bone; age: 34; Sex: female; tumor stage: normal tissue
  • GSM6254241 A-2 normal tissue Control marker detected. bone tissue: bone; age: 40; Sex: male; tumor stage: normal tissue
  • GSM6254242 A-3 normal tissue Control marker detected. bone tissue: bone; age: 50; Sex: male; tumor stage: normal tissue
  • GSM6254243 A-4 normal tissue Control marker detected. bone tissue: bone; age: 36; Sex: female; tumor stage: normal tissue
  • GSM6254244 A-5 normal tissue Control marker detected. bone tissue: bone; age: 45; Sex: male; tumor stage: normal tissue

Unassigned samples

Samples with no explicit case or control marker.

0

No samples

Excluded samples

Samples excluded from grouping by hard exclusion rules.

0

No samples

Ambiguous samples

Samples that need manual review before trusting grouping.

0

No samples

Metadata Quality Components

Persisted metadata quality

70 pts
Clarity
70%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata was not normalized. Tissue clarity: Tissue metadata was not normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Detected Sample Groups

normal tissue

5 samples
  • GSM6254240 A-1 bone tissue: bone; age: 34; Sex: female; tumor stage: normal tissue
  • GSM6254241 A-2 bone tissue: bone; age: 40; Sex: male; tumor stage: normal tissue
  • GSM6254242 A-3 bone tissue: bone; age: 50; Sex: male; tumor stage: normal tissue
  • GSM6254243 A-4 bone tissue: bone; age: 36; Sex: female; tumor stage: normal tissue
  • GSM6254244 A-5 bone tissue: bone; age: 45; Sex: male; tumor stage: normal tissue

tumor sample

5 samples
  • GSM6254245 T-1 bone tissue: bone; age: 34; Sex: female; tumor stage: stage I
  • GSM6254246 T-2 bone tissue: bone; age: 40; Sex: male; tumor stage: stage I
  • GSM6254247 T-3 bone tissue: bone; age: 50; Sex: male; tumor stage: stage II
  • GSM6254248 T-4 bone tissue: bone; age: 36; Sex: female; tumor stage: stage I
  • GSM6254249 T-5 bone tissue: bone; age: 45; Sex: male; tumor stage: stage II

Score Breakdown

50%

relevance

  • Organism normalized.
  • Assay type normalized.
5%

comparison suitability

  • Tumor and normal sample groups detected.
  • No excluded sample type flags detected.
  • Tumor/normal design boosted for colorectal tumor-vs-normal tissue triage.
  • Patient tissue or biopsy specimens boosted for tissue comparison triage.
  • Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking.
70%

metadata quality

  • Sample source clarity: All samples have source metadata and clear GSE/GSM accessions.
  • Group clarity: Rule-based grouping found both case and control samples.
  • Disease clarity: Disease or condition metadata was not normalized.
  • Tissue clarity: Tissue metadata was not normalized.
  • Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Replicate clarity: No pooled sample or technical replicate flags detected.
  • Data availability clarity: Dataset-level processed or raw data availability is explicit.
100%

data availability

  • Processed data available.
  • Raw data available.
45%

overall

  • Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because colorectal/CRC disease context is not explicit.

Sample Links

10 samples

Review Audit Trail

0 decisions

No review decisions have been stored for this dataset.