Siftome Phase 3L

GSE210790

Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic peptides [circRNA-seq]

Not suitable Dataset does not meet the current suitability threshold.
Sample grouping CSV Contrast CSV DESeq2 metadata CSV R handoff notes Handoff report Download instructions Open GEO dataset
Source
GEO
Search intent
Patient tissue tumor-vs-normal
Intent behavior
search-intent-behavior-v1
Submission date
2022-08-09
Last update
2024-01-25
Organization
Sun Yat-Sen University
Department
Not available
Public date
2023-10-08
Experiment types
Non-coding RNA profiling by high throughput sequencing
Platforms
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Series type
SubSeries
SubSeries
Not available
BioProject
PRJNA867551
Supplementary files
XLSX: GSE210790_Tissues_circRNA_expression.xlsx
Organism
Homo sapiens
Assay
bulk RNA-seq
Samples
12
Study design
Tumor vs unmatched normal
Specimen/source
Tissue
Scoring version
intent-aware-scoring-v15
Ranking batch
b69568dd1e4fe1b9ee2d880bf5495d748a7e4c5c11e4107f02528c3be0e76012
Ranking created
2026-06-05T20:20:27.088676Z
Warning version
intent-aware-warnings-v2

Current Intent Interpretation

Patient tissue tumor-vs-normal

Expectations

Organism
Homo sapiens
Assay
bulk RNA-seq
Specimen/source
patient tissue or biopsy
Controls
matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control

Rules

Default filters
Human only; Bulk RNA-seq only; Tumor-normal only; Tissue or biopsy only; Hide biofluid/model systems
Warning rules
missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
Score caps
non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
Downgraded contexts
microarray unless explicitly enabled, biofluid-only datasets, cell-line datasets, organoid datasets, xenograft or PDX datasets, non-colorectal disease contexts, or treatment-only experiments

Study Classification

Tumor vs unmatched normal Tissue

Analysis Readiness

Review before analysis
97% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

  • Secondary RNA assay context should be analyzed separately from ordinary bulk RNA-seq.

Next Steps

  • Review blockers and update sample grouping or dataset selection before analysis.

Analysis Preparation Checklist

5/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Still scan the grouping table for biology-specific ambiguity.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source links preserved

Ready

The dataset and sample accessions can be linked back to GEO.

Keep GEO dataset and sample links with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

  • Analysis readiness has blockers that must be resolved before DE.
  • Assay context may require expert handling before DESeq2-style analysis.

Why This Is Ranked Here

Patient tissue tumor-vs-normal
Not suitable Dataset does not meet the current suitability threshold.

Score Components

  • relevance 100% Disease or condition metadata normalized. Organism normalized. Assay type normalized. Tissue metadata normalized.
  • comparison suitability 0% Tumor and normal sample groups detected. No excluded sample type flags detected. Tumor/normal design boosted for colorectal tumor-vs-normal tissue triage. Patient tissue or biopsy specimens boosted for tissue comparison triage. Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking. Non-colorectal cancer context downgraded for colorectal tumor-vs-normal tissue ranking.
  • metadata quality 100% Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Tissue metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.
  • data availability 100% Processed data available. Raw data available.
  • overall 34% Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability. Overall score capped because comparison suitability is weak for the selected search intent. Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq. Overall score capped because tumor/normal grouping is from a non-colorectal cancer context.

Derived Classifications

  • Organism Homo sapiens Organism remains rule-derived: Homo sapiens.
  • Assay bulk RNA-seq Assay remains rule-derived: bulk RNA-seq.
  • Study design Tumor vs unmatched normal Study design remains rule-derived: Tumor vs unmatched normal.
  • Specimen/source Tissue Specimen/source remains rule-derived: Tissue.
  • Likely case group tumor sample 6 samples
  • Likely control group normal tissue 6 samples

Warnings

  • SECONDARY_ASSAY_CONTEXT warning Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.

Intent Interpretation

  • Active intent Patient tissue tumor-vs-normal Ranks human colorectal tissue or biopsy cohorts where tumor samples can be compared with normal controls.
  • Organism expectation Homo sapiens Dataset organism is interpreted as Homo sapiens.
  • Assay expectation bulk RNA-seq Dataset assay is interpreted as bulk RNA-seq.
  • Specimen assumption patient tissue or biopsy Derived specimen/source is Tissue.
  • Control-group assumption matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control Derived study design is Tumor vs unmatched normal; likely groups are tumor sample vs normal tissue.
  • Score caps Applied when matching conditions are present non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
  • Warning rules 1 active warning missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
  • Downgrade or exclusion reason Downgraded disease context: not a colorectal/GI cancer cohort. Derived from current-intent ranking reasons and warnings.

Applied Review Decisions

No active review decisions affect this ranking.

Ranking Facts

  • Recommendation Not suitable Dataset does not meet the current suitability threshold.
  • Supporting fact Tumor vs unmatched normal · Tissue · suitability 0%. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized assay: bulk RNA-seq is the active assay expectation. Contributed to match or upgrade evidence.
  • Supporting fact Downgraded disease context: not a colorectal/GI cancer cohort. Contributed to match or upgrade evidence.
  • Supporting fact Processed data is available for downstream review. Contributed to match or upgrade evidence.
  • Supporting fact 1 warning require review. Contributed to match or upgrade evidence.
  • Caution fact Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected. Contributed to downgrade or manual-review evidence.
  • Caution fact Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Non-colorectal cancer context downgraded for colorectal tumor-vs-normal tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because comparison suitability is weak for the selected search intent. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because tumor/normal grouping is from a non-colorectal cancer context. Contributed to downgrade or manual-review evidence.
  • Caution fact Downgraded disease context: not a colorectal/GI cancer cohort. Contributed to downgrade or manual-review evidence.
  • Caution fact Comparison suitability score is below the Phase 1 recommended threshold. Contributed to downgrade or manual-review evidence.

Manual Corrections

0 active

Source Evidence

4 sources

GEO

Primary source

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Dataset accession
GSE210790
Sample records
12 GSM samples
  • GEO has priority for original metadata under the Phase 3J source rules.
  • Processed data: available.
  • Raw data: available.
  • No external source conflict is present in the current runtime data.

recount3

Not imported

Planned trusted source for processed count availability.

GEO accession
GSE210790
  • No recount3 project identifier has been imported for this dataset.
  • Once imported, recount3 has priority for processed count availability.
  • The recount3 source filter excludes this dataset until that linkage exists.
No recount3 sync data available.

Expression Atlas

Not imported

Planned source for curated expression experiment links.

GEO accession
GSE210790
  • No Expression Atlas experiment identifier has been imported for this dataset.
  • Once imported, Expression Atlas has priority for curated expression experiment links.
  • The Expression Atlas source filter excludes this dataset until that linkage exists.
No Expression Atlas sync data available.

PubMed

Unavailable

Publication context when PubMed identifiers are already known.

GEO accession
GSE210790
  • No PubMed identifier is present in the current runtime metadata.
  • No live PubMed search is performed from the dataset detail page.
No publication identifier imported.

Dataset Feedback

0 stored

Original GEO Metadata

dataset_accession: GSE210790
dataset_title: Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic peptides [circRNA-seq]
organism: Homo sapiens
assay_type: bulk RNA-seq
processed_data_available: true
raw_data_available: true
submission_date: 2022-08-09
last_update_date: 2024-01-25
organization_name: Sun Yat-Sen University
department: Not available
public_date: 2023-10-08
experiment_types: Non-coding RNA profiling by high throughput sequencing
platforms: GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
sub_series: Not available
bioproject: PRJNA867551
supplementary_files: XLSX: GSE210790_Tissues_circRNA_expression.xlsx
series_type: SubSeries

Why It Matched

  • Tumor vs unmatched normal · Tissue · suitability 0%.
  • Prioritized assay: bulk RNA-seq is the active assay expectation.
  • Downgraded disease context: not a colorectal/GI cancer cohort.
  • Processed data is available for downstream review.
  • 1 warning require review.

Why It May Not Be Suitable

  • Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.
  • Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
  • Non-colorectal cancer context downgraded for colorectal tumor-vs-normal tissue ranking.
  • Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.
  • Overall score capped because tumor/normal grouping is from a non-colorectal cancer context.
  • Downgraded disease context: not a colorectal/GI cancer cohort.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Warnings

  • warning SECONDARY_ASSAY_CONTEXT Secondary RNA assay context such as small RNA, miRNA, circRNA, or non-coding RNA was detected.

Normalized Fields

32 fields
Field Value Source Origin Confidence Evidence Reason
assay_type bulk RNA-seq dataset GSE210790 Runtime Siftome inference GEO:dataset:GSE210790:fab4a40c9730efb43919e3123574144478a96602b75de3af677a244ddaa860b2 high confidence bulk rna-seq dataset_accession: GSE210790 dataset_title: Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic peptides [circRNA-seq] organism: Homo sapiens assay_ty... keyword match keyword match: bulk rna-seq
disease breast cancer sample GSM6437657 Runtime Siftome inference GEO:sample:GSM6437657:f559585283a04f196c7789982f7e212875c71261ff3e136b6491fd1fc2f62f28 high confidence breast cancer sample_accession: GSM6437657 sample_title: T1 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 46; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary disease match: breast cancer
disease breast cancer sample GSM6437658 Runtime Siftome inference GEO:sample:GSM6437658:967bbbeb9bf400e5f19930bff9205861fc309130f79bfea058c6350ddbf69672 high confidence breast cancer sample_accession: GSM6437658 sample_title: T2 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 52; ethnicity: Han nationality; tumor grade: III; outco... controlled vocabulary controlled vocabulary disease match: breast cancer
disease breast cancer sample GSM6437659 Runtime Siftome inference GEO:sample:GSM6437659:acf95347c09c0def8fc66103bc5a27430619442880e8c6d6fb25c78a836963e5 high confidence breast cancer sample_accession: GSM6437659 sample_title: T3 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 47; ethnicity: Han nationality; tumor grade: III; outco... controlled vocabulary controlled vocabulary disease match: breast cancer
disease breast cancer sample GSM6437660 Runtime Siftome inference GEO:sample:GSM6437660:b7c6e34f44b4572901eb47884922a98d2498f0d46dfc69c636d6951a3187e87f high confidence breast cancer sample_accession: GSM6437660 sample_title: T4 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 56; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary disease match: breast cancer
disease breast cancer sample GSM6437661 Runtime Siftome inference GEO:sample:GSM6437661:192c1a9f801778c98d9633c5df1440e8526481f19e919f1fb45f9729c72a027b high confidence breast cancer sample_accession: GSM6437661 sample_title: T5 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 49; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary disease match: breast cancer
disease breast cancer sample GSM6437662 Runtime Siftome inference GEO:sample:GSM6437662:2ee5c9b803c083f0b098c5814595909f761486bb51410fd0758d8465fdef388e high confidence breast cancer sample_accession: GSM6437662 sample_title: T6 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 51; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary disease match: breast cancer
organism Homo sapiens dataset GSE210790 Runtime Siftome inference GEO:dataset:GSE210790:fab4a40c9730efb43919e3123574144478a96602b75de3af677a244ddaa860b2 high confidence homo sapiens dataset_accession: GSE210790 dataset_title: Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic peptides [circRNA-seq] organism: Homo sapiens assay_ty... keyword match keyword match: homo sapiens
sample_type normal tissue sample GSM6437651 Runtime Siftome inference GEO:sample:GSM6437651:7d8c49c96ea309424156d30d9b5438309a1ed6d63998fa341c544459052e87de low confidence normal sample_accession: GSM6437651 sample_title: N1 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 46; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6437651 Runtime Siftome inference GEO:sample:GSM6437651:7d8c49c96ea309424156d30d9b5438309a1ed6d63998fa341c544459052e87de low confidence tumor sample_accession: GSM6437651 sample_title: N1 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 46; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM6437652 Runtime Siftome inference GEO:sample:GSM6437652:3a44744f69a3a50e73292a4899aab2d9b07807536a8df7c822e68feb10e2a3a2 low confidence normal sample_accession: GSM6437652 sample_title: N2 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 52; ethnicity: Han nationality; tumor grade: III; outco... controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6437652 Runtime Siftome inference GEO:sample:GSM6437652:3a44744f69a3a50e73292a4899aab2d9b07807536a8df7c822e68feb10e2a3a2 low confidence tumor sample_accession: GSM6437652 sample_title: N2 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 52; ethnicity: Han nationality; tumor grade: III; outco... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM6437653 Runtime Siftome inference GEO:sample:GSM6437653:578abd7e7d38fcc953166e8ef6ed5d3d1fbaf3d86814ffa5be18bec13d222bfd low confidence normal sample_accession: GSM6437653 sample_title: N3 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 47; ethnicity: Han nationality; tumor grade: III; outco... controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6437653 Runtime Siftome inference GEO:sample:GSM6437653:578abd7e7d38fcc953166e8ef6ed5d3d1fbaf3d86814ffa5be18bec13d222bfd low confidence tumor sample_accession: GSM6437653 sample_title: N3 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 47; ethnicity: Han nationality; tumor grade: III; outco... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM6437654 Runtime Siftome inference GEO:sample:GSM6437654:03b0be67359cc6e645463631709ed50d751ec2abb7bc47fdbb52293f6e1a790d low confidence normal sample_accession: GSM6437654 sample_title: N4 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 56; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6437654 Runtime Siftome inference GEO:sample:GSM6437654:03b0be67359cc6e645463631709ed50d751ec2abb7bc47fdbb52293f6e1a790d low confidence tumor sample_accession: GSM6437654 sample_title: N4 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 56; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM6437655 Runtime Siftome inference GEO:sample:GSM6437655:d947f445de97702bacfda76b34d8b5d068a79531f226dc3a5775fe97084895b0 low confidence normal sample_accession: GSM6437655 sample_title: N5 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 49; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6437655 Runtime Siftome inference GEO:sample:GSM6437655:d947f445de97702bacfda76b34d8b5d068a79531f226dc3a5775fe97084895b0 low confidence tumor sample_accession: GSM6437655 sample_title: N5 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 49; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM6437656 Runtime Siftome inference GEO:sample:GSM6437656:2a9c327ec8bbf68aa8b7385e30d06b31634627c1eb3b4dfe0cb86016a6f17cff low confidence normal sample_accession: GSM6437656 sample_title: N6 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 51; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: normal
sample_type tumor sample sample GSM6437656 Runtime Siftome inference GEO:sample:GSM6437656:2a9c327ec8bbf68aa8b7385e30d06b31634627c1eb3b4dfe0cb86016a6f17cff low confidence tumor sample_accession: GSM6437656 sample_title: N6 (circRNA-seq) source_name: normal tissue characteristics: Sex: female; age: 51; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6437657 Runtime Siftome inference GEO:sample:GSM6437657:f559585283a04f196c7789982f7e212875c71261ff3e136b6491fd1fc2f62f28 low confidence tumor sample_accession: GSM6437657 sample_title: T1 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 46; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6437658 Runtime Siftome inference GEO:sample:GSM6437658:967bbbeb9bf400e5f19930bff9205861fc309130f79bfea058c6350ddbf69672 low confidence tumor sample_accession: GSM6437658 sample_title: T2 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 52; ethnicity: Han nationality; tumor grade: III; outco... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6437659 Runtime Siftome inference GEO:sample:GSM6437659:acf95347c09c0def8fc66103bc5a27430619442880e8c6d6fb25c78a836963e5 low confidence tumor sample_accession: GSM6437659 sample_title: T3 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 47; ethnicity: Han nationality; tumor grade: III; outco... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6437660 Runtime Siftome inference GEO:sample:GSM6437660:b7c6e34f44b4572901eb47884922a98d2498f0d46dfc69c636d6951a3187e87f low confidence tumor sample_accession: GSM6437660 sample_title: T4 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 56; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6437661 Runtime Siftome inference GEO:sample:GSM6437661:192c1a9f801778c98d9633c5df1440e8526481f19e919f1fb45f9729c72a027b low confidence tumor sample_accession: GSM6437661 sample_title: T5 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 49; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM6437662 Runtime Siftome inference GEO:sample:GSM6437662:2ee5c9b803c083f0b098c5814595909f761486bb51410fd0758d8465fdef388e low confidence tumor sample_accession: GSM6437662 sample_title: T6 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 51; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary sample type match: tumor
tissue breast sample GSM6437657 Runtime Siftome inference GEO:sample:GSM6437657:f559585283a04f196c7789982f7e212875c71261ff3e136b6491fd1fc2f62f28 low confidence breast sample_accession: GSM6437657 sample_title: T1 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 46; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary tissue match: breast
tissue breast sample GSM6437658 Runtime Siftome inference GEO:sample:GSM6437658:967bbbeb9bf400e5f19930bff9205861fc309130f79bfea058c6350ddbf69672 low confidence breast sample_accession: GSM6437658 sample_title: T2 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 52; ethnicity: Han nationality; tumor grade: III; outco... controlled vocabulary controlled vocabulary tissue match: breast
tissue breast sample GSM6437659 Runtime Siftome inference GEO:sample:GSM6437659:acf95347c09c0def8fc66103bc5a27430619442880e8c6d6fb25c78a836963e5 low confidence breast sample_accession: GSM6437659 sample_title: T3 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 47; ethnicity: Han nationality; tumor grade: III; outco... controlled vocabulary controlled vocabulary tissue match: breast
tissue breast sample GSM6437660 Runtime Siftome inference GEO:sample:GSM6437660:b7c6e34f44b4572901eb47884922a98d2498f0d46dfc69c636d6951a3187e87f low confidence breast sample_accession: GSM6437660 sample_title: T4 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 56; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary tissue match: breast
tissue breast sample GSM6437661 Runtime Siftome inference GEO:sample:GSM6437661:192c1a9f801778c98d9633c5df1440e8526481f19e919f1fb45f9729c72a027b low confidence breast sample_accession: GSM6437661 sample_title: T5 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 49; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary tissue match: breast
tissue breast sample GSM6437662 Runtime Siftome inference GEO:sample:GSM6437662:2ee5c9b803c083f0b098c5814595909f761486bb51410fd0758d8465fdef388e low confidence breast sample_accession: GSM6437662 sample_title: T6 (circRNA-seq) source_name: cancer tissue characteristics: Sex: female; age: 51; ethnicity: Han nationality; tumor grade: II; outcom... controlled vocabulary controlled vocabulary tissue match: breast

Sample Group Preview

Possible case samples

Samples currently treated as the comparison case group.

6
  • GSM6437657 T1 (circRNA-seq) tumor sample Case marker detected. cancer tissue Sex: female; age: 46; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: breast cancer tissue
  • GSM6437658 T2 (circRNA-seq) tumor sample Case marker detected. cancer tissue Sex: female; age: 52; ethnicity: Han nationality; tumor grade: III; outcome: recovery; tissue: breast cancer tissue
  • GSM6437659 T3 (circRNA-seq) tumor sample Case marker detected. cancer tissue Sex: female; age: 47; ethnicity: Han nationality; tumor grade: III; outcome: recovery; tissue: breast cancer tissue
  • GSM6437660 T4 (circRNA-seq) tumor sample Case marker detected. cancer tissue Sex: female; age: 56; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: breast cancer tissue
  • GSM6437661 T5 (circRNA-seq) tumor sample Case marker detected. cancer tissue Sex: female; age: 49; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: breast cancer tissue
  • GSM6437662 T6 (circRNA-seq) tumor sample Case marker detected. cancer tissue Sex: female; age: 51; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: breast cancer tissue

Possible control samples

Samples currently treated as controls or baseline.

6
  • GSM6437651 N1 (circRNA-seq) normal tissue Control marker detected. normal tissue Sex: female; age: 46; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: normal tissue
  • GSM6437652 N2 (circRNA-seq) normal tissue Control marker detected. normal tissue Sex: female; age: 52; ethnicity: Han nationality; tumor grade: III; outcome: recovery; tissue: normal tissue
  • GSM6437653 N3 (circRNA-seq) normal tissue Control marker detected. normal tissue Sex: female; age: 47; ethnicity: Han nationality; tumor grade: III; outcome: recovery; tissue: normal tissue
  • GSM6437654 N4 (circRNA-seq) normal tissue Control marker detected. normal tissue Sex: female; age: 56; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: normal tissue
  • GSM6437655 N5 (circRNA-seq) normal tissue Control marker detected. normal tissue Sex: female; age: 49; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: normal tissue
  • GSM6437656 N6 (circRNA-seq) normal tissue Control marker detected. normal tissue Sex: female; age: 51; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: normal tissue

Unassigned samples

Samples with no explicit case or control marker.

0

No samples

Excluded samples

Samples excluded from grouping by hard exclusion rules.

0

No samples

Ambiguous samples

Samples that need manual review before trusting grouping.

0

No samples

Metadata Quality Components

Persisted metadata quality

100 pts
Clarity
100%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Tissue metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Detected Sample Groups

normal tissue

6 samples
  • GSM6437651 N1 (circRNA-seq) normal tissue Sex: female; age: 46; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: normal tissue
  • GSM6437652 N2 (circRNA-seq) normal tissue Sex: female; age: 52; ethnicity: Han nationality; tumor grade: III; outcome: recovery; tissue: normal tissue
  • GSM6437653 N3 (circRNA-seq) normal tissue Sex: female; age: 47; ethnicity: Han nationality; tumor grade: III; outcome: recovery; tissue: normal tissue
  • GSM6437654 N4 (circRNA-seq) normal tissue Sex: female; age: 56; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: normal tissue
  • GSM6437655 N5 (circRNA-seq) normal tissue Sex: female; age: 49; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: normal tissue
  • GSM6437656 N6 (circRNA-seq) normal tissue Sex: female; age: 51; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: normal tissue

tumor sample

6 samples
  • GSM6437657 T1 (circRNA-seq) cancer tissue Sex: female; age: 46; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: breast cancer tissue
  • GSM6437658 T2 (circRNA-seq) cancer tissue Sex: female; age: 52; ethnicity: Han nationality; tumor grade: III; outcome: recovery; tissue: breast cancer tissue
  • GSM6437659 T3 (circRNA-seq) cancer tissue Sex: female; age: 47; ethnicity: Han nationality; tumor grade: III; outcome: recovery; tissue: breast cancer tissue
  • GSM6437660 T4 (circRNA-seq) cancer tissue Sex: female; age: 56; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: breast cancer tissue
  • GSM6437661 T5 (circRNA-seq) cancer tissue Sex: female; age: 49; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: breast cancer tissue
  • GSM6437662 T6 (circRNA-seq) cancer tissue Sex: female; age: 51; ethnicity: Han nationality; tumor grade: II; outcome: recovery; tissue: breast cancer tissue

Score Breakdown

100%

relevance

  • Disease or condition metadata normalized.
  • Organism normalized.
  • Assay type normalized.
  • Tissue metadata normalized.
0%

comparison suitability

  • Tumor and normal sample groups detected.
  • No excluded sample type flags detected.
  • Tumor/normal design boosted for colorectal tumor-vs-normal tissue triage.
  • Patient tissue or biopsy specimens boosted for tissue comparison triage.
  • Small RNA, miRNA, circRNA, or extracellular-vesicle RNA context downgraded for primary mRNA tissue ranking.
  • Non-colorectal cancer context downgraded for colorectal tumor-vs-normal tissue ranking.
100%

metadata quality

  • Sample source clarity: All samples have source metadata and clear GSE/GSM accessions.
  • Group clarity: Rule-based grouping found both case and control samples.
  • Disease clarity: Disease or condition metadata normalized.
  • Tissue clarity: Tissue metadata normalized.
  • Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Replicate clarity: No pooled sample or technical replicate flags detected.
  • Data availability clarity: Dataset-level processed or raw data availability is explicit.
100%

data availability

  • Processed data available.
  • Raw data available.
34%

overall

  • Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because secondary RNA assays are not primary mRNA tissue RNA-seq.
  • Overall score capped because tumor/normal grouping is from a non-colorectal cancer context.

Sample Links

12 samples

Review Audit Trail

0 decisions

No review decisions have been stored for this dataset.