Siftome Phase 3L

GSE226307

The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer

Not suitable Dataset does not meet the current suitability threshold.
Sample grouping CSV Contrast CSV DESeq2 metadata CSV R handoff notes Handoff report Download instructions Open GEO dataset
Source
GEO
Search intent
Patient tissue tumor-vs-normal
Intent behavior
search-intent-behavior-v1
Submission date
2023-02-28
Last update
2023-07-01
Organization
UCL
Department
School of Pharmacy
Public date
2023-04-01
Experiment types
Expression profiling by high throughput sequencing
Platforms
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Series type
Series
SubSeries
Not available
BioProject
PRJNA939626
Supplementary files
XLSX: GSE226307_PDAC-vs-Normal-Pancreas-RNA-seq.xlsx; XLSX: GSE226307_Processed-RNA-seq-counts.xlsx
Organism
Homo sapiens
Assay
bulk RNA-seq
Samples
7
Study design
Tumor vs unmatched normal
Specimen/source
Tissue
Scoring version
intent-aware-scoring-v15
Ranking batch
b69568dd1e4fe1b9ee2d880bf5495d748a7e4c5c11e4107f02528c3be0e76012
Ranking created
2026-06-05T20:20:27.088676Z
Warning version
intent-aware-warnings-v2

Current Intent Interpretation

Patient tissue tumor-vs-normal

Expectations

Organism
Homo sapiens
Assay
bulk RNA-seq
Specimen/source
patient tissue or biopsy
Controls
matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control

Rules

Default filters
Human only; Bulk RNA-seq only; Tumor-normal only; Tissue or biopsy only; Hide biofluid/model systems
Warning rules
missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
Score caps
non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
Downgraded contexts
microarray unless explicitly enabled, biofluid-only datasets, cell-line datasets, organoid datasets, xenograft or PDX datasets, non-colorectal disease contexts, or treatment-only experiments

Study Classification

Tumor vs unmatched normal Tissue

Analysis Readiness

Review before analysis
87% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

20/20 pts

Each contrast group has at least 2 samples.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

12/15 pts

All non-excluded samples are assigned; excluded samples should still be confirmed.

Blocking warnings

0/10 pts

Critical warnings must be resolved before downstream analysis.

Metadata normalization

10/10 pts

Metadata quality is high enough to support downstream handoff.

Blockers

  • Critical dataset warnings must be resolved.

Next Steps

  • Confirm excluded samples before creating the final analysis metadata file.
  • Resolve critical warnings before downstream analysis.

Analysis Preparation Checklist

4/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Ready

Both groups meet the minimum of 2 samples.

Confirm whether the cohort is large enough for the intended statistical analysis.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Still scan the grouping table for biology-specific ambiguity.

Exclusion decisions recorded

Needs review

2 samples have hard exclusion flags in the proposed grouping.

Confirm excluded samples and preserve the reason in the analysis handoff.

Source links preserved

Ready

The dataset and sample accessions can be linked back to GEO.

Keep GEO dataset and sample links with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

  • Analysis readiness has blockers that must be resolved before DE.
  • Critical dataset warnings are present.

Why This Is Ranked Here

Patient tissue tumor-vs-normal
Not suitable Dataset does not meet the current suitability threshold.

Score Components

  • relevance 100% Disease or condition metadata normalized. Organism normalized. Assay type normalized. Tissue metadata normalized.
  • comparison suitability 0% Case and control sample groups detected: pancreatic cancer vs normal tissue. No excluded sample type flags detected. Tumor/normal design boosted for colorectal tumor-vs-normal tissue triage. Patient tissue or biopsy specimens boosted for tissue comparison triage. Non-colorectal gastrointestinal cancer context downgraded for colorectal tissue ranking. Animal sample markers downgraded because this is a human dataset ranking.
  • metadata quality 100% Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Tissue metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.
  • data availability 100% Processed data available. Raw data available.
  • overall 34% Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability. Overall score capped because comparison suitability is weak for the selected search intent. Overall score capped because fewer than ten samples limit cohort confidence. Overall score capped because gastrointestinal context is not explicit colorectal/CRC.

Derived Classifications

  • Organism Homo sapiens Organism remains rule-derived: Homo sapiens.
  • Assay bulk RNA-seq Assay remains rule-derived: bulk RNA-seq.
  • Study design Tumor vs unmatched normal Study design remains rule-derived: Tumor vs unmatched normal.
  • Specimen/source Tissue Specimen/source remains rule-derived: Tissue.
  • Likely case group pancreatic cancer 2 samples
  • Likely control group normal tissue 3 samples

Warnings

  • ANIMAL_SAMPLES_IN_HUMAN_DATASET critical Animal sample markers were detected in a human dataset.

Intent Interpretation

  • Active intent Patient tissue tumor-vs-normal Ranks human colorectal tissue or biopsy cohorts where tumor samples can be compared with normal controls.
  • Organism expectation Homo sapiens Dataset organism is interpreted as Homo sapiens.
  • Assay expectation bulk RNA-seq Dataset assay is interpreted as bulk RNA-seq.
  • Specimen assumption patient tissue or biopsy Derived specimen/source is Tissue.
  • Control-group assumption matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control Derived study design is Tumor vs unmatched normal; likely groups are pancreatic cancer vs normal tissue.
  • Score caps Applied when matching conditions are present non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
  • Warning rules 1 active warning missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
  • Downgrade or exclusion reason Downgraded disease context: gastrointestinal cancer is present but colorectal metadata is not explicit. Derived from current-intent ranking reasons and warnings.

Applied Review Decisions

No active review decisions affect this ranking.

Ranking Facts

  • Recommendation Not suitable Dataset does not meet the current suitability threshold.
  • Supporting fact Tumor vs unmatched normal · Tissue · suitability 0%. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized assay: bulk RNA-seq is the active assay expectation. Contributed to match or upgrade evidence.
  • Supporting fact Downgraded disease context: gastrointestinal cancer is present but colorectal metadata is not explicit. Contributed to match or upgrade evidence.
  • Supporting fact Processed data is available for downstream review. Contributed to match or upgrade evidence.
  • Supporting fact 1 warning require review. Contributed to match or upgrade evidence.
  • Caution fact Animal sample markers were detected in a human dataset. Contributed to downgrade or manual-review evidence.
  • Caution fact Non-colorectal gastrointestinal cancer context downgraded for colorectal tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Animal sample markers downgraded because this is a human dataset ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because comparison suitability is weak for the selected search intent. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because fewer than ten samples limit cohort confidence. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because gastrointestinal context is not explicit colorectal/CRC. Contributed to downgrade or manual-review evidence.
  • Caution fact Downgraded disease context: gastrointestinal cancer is present but colorectal metadata is not explicit. Contributed to downgrade or manual-review evidence.
  • Caution fact Comparison suitability score is below the Phase 1 recommended threshold. Contributed to downgrade or manual-review evidence.

Manual Corrections

0 active

Source Evidence

4 sources

GEO

Primary source

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Dataset accession
GSE226307
Sample records
7 GSM samples
  • GEO has priority for original metadata under the Phase 3J source rules.
  • Processed data: available.
  • Raw data: available.
  • No external source conflict is present in the current runtime data.

recount3

Not imported

Planned trusted source for processed count availability.

GEO accession
GSE226307
  • No recount3 project identifier has been imported for this dataset.
  • Once imported, recount3 has priority for processed count availability.
  • The recount3 source filter excludes this dataset until that linkage exists.
No recount3 sync data available.

Expression Atlas

Not imported

Planned source for curated expression experiment links.

GEO accession
GSE226307
  • No Expression Atlas experiment identifier has been imported for this dataset.
  • Once imported, Expression Atlas has priority for curated expression experiment links.
  • The Expression Atlas source filter excludes this dataset until that linkage exists.
No Expression Atlas sync data available.

PubMed

Unavailable

Publication context when PubMed identifiers are already known.

GEO accession
GSE226307
  • No PubMed identifier is present in the current runtime metadata.
  • No live PubMed search is performed from the dataset detail page.
No publication identifier imported.

Dataset Feedback

0 stored

Original GEO Metadata

dataset_accession: GSE226307
dataset_title: The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer
organism: Homo sapiens
assay_type: bulk RNA-seq
processed_data_available: true
raw_data_available: true
submission_date: 2023-02-28
last_update_date: 2023-07-01
organization_name: UCL
department: School of Pharmacy
public_date: 2023-04-01
experiment_types: Expression profiling by high throughput sequencing
platforms: GPL18573 Illumina NextSeq 500 (Homo sapiens)
sub_series: Not available
bioproject: PRJNA939626
supplementary_files: XLSX: GSE226307_PDAC-vs-Normal-Pancreas-RNA-seq.xlsx; XLSX: GSE226307_Processed-RNA-seq-counts.xlsx
series_type: Series

Why It Matched

  • Tumor vs unmatched normal · Tissue · suitability 0%.
  • Prioritized assay: bulk RNA-seq is the active assay expectation.
  • Downgraded disease context: gastrointestinal cancer is present but colorectal metadata is not explicit.
  • Processed data is available for downstream review.
  • 1 warning require review.

Why It May Not Be Suitable

  • Animal sample markers were detected in a human dataset.
  • Non-colorectal gastrointestinal cancer context downgraded for colorectal tissue ranking.
  • Animal sample markers downgraded because this is a human dataset ranking.
  • Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because fewer than ten samples limit cohort confidence.
  • Overall score capped because gastrointestinal context is not explicit colorectal/CRC.
  • Downgraded disease context: gastrointestinal cancer is present but colorectal metadata is not explicit.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Warnings

  • critical ANIMAL_SAMPLES_IN_HUMAN_DATASET Animal sample markers were detected in a human dataset.

Normalized Fields

18 fields
Field Value Source Origin Confidence Evidence Reason
assay_type bulk RNA-seq dataset GSE226307 Runtime Siftome inference GEO:dataset:GSE226307:213a8b35bca67a5a608fa9d0f94e5678819a23f296e0b18ca8ef8d3d0a4f639d high confidence bulk rna-seq dataset_accession: GSE226307 dataset_title: The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Ca... keyword match keyword match: bulk rna-seq
disease pancreatic cancer dataset GSE226307 Runtime Siftome inference GEO:dataset:GSE226307:213a8b35bca67a5a608fa9d0f94e5678819a23f296e0b18ca8ef8d3d0a4f639d high confidence pancreatic cancer dataset_accession: GSE226307 dataset_title: The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Ca... controlled vocabulary controlled vocabulary disease match: pancreatic cancer
disease pancreatic cancer sample GSM7071068 Runtime Siftome inference GEO:sample:GSM7071068:e9461e7d1fe8eb22889ce4e4782b155c5167228b88b439e085a2d881cdc3652f medium confidence pdac sample_accession: GSM7071068 sample_title: Poorly differentiated PDAC 1 [R2971] source_name: pancreas characteristics: tissue: pancreas; tissue type: Poorly differentiated PDAC ... controlled vocabulary controlled vocabulary disease match: pdac
disease pancreatic cancer sample GSM7071069 Runtime Siftome inference GEO:sample:GSM7071069:67ac6172a7e734dd7844b3096d0bc3fc557fe0faaa765765fe6f6fc3f91e5d1d medium confidence pdac sample_accession: GSM7071069 sample_title: Poorly differentiated PDAC 2 [R2944] source_name: pancreas characteristics: tissue: pancreas; tissue type: Poorly differentiated PDAC ... controlled vocabulary controlled vocabulary disease match: pdac
disease pancreatic cancer sample GSM7071070 Runtime Siftome inference GEO:sample:GSM7071070:147b95da5fca4ab7c108675e89dc6091e0cc142a5089c7dff8f0a075bb212b82 medium confidence pdac sample_accession: GSM7071070 sample_title: Moderately differentiated PDAC 1 [R2824] source_name: pancreas characteristics: tissue: pancreas; tissue type: Moderately differentiat... controlled vocabulary controlled vocabulary disease match: pdac
disease pancreatic cancer sample GSM7071071 Runtime Siftome inference GEO:sample:GSM7071071:6028373bf1ea69a76c57e6f0be114b358065449b209e55aaa54bb4770db6c3ff medium confidence pdac sample_accession: GSM7071071 sample_title: Moderately differentiated PDAC 2 [R2700] source_name: pancreas characteristics: tissue: pancreas; tissue type: Moderately differentiat... controlled vocabulary controlled vocabulary disease match: pdac
organism Homo sapiens dataset GSE226307 Runtime Siftome inference GEO:dataset:GSE226307:213a8b35bca67a5a608fa9d0f94e5678819a23f296e0b18ca8ef8d3d0a4f639d high confidence homo sapiens dataset_accession: GSE226307 dataset_title: The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Ca... keyword match keyword match: homo sapiens
sample_type normal tissue sample GSM7071072 Runtime Siftome inference GEO:sample:GSM7071072:42b50ad4de630f549fe3688654b9ef086c3520d81b12e83f48deda18334723c9 low confidence normal sample_accession: GSM7071072 sample_title: Normal pancreatic tissue 1 [CR560569] source_name: pancreas characteristics: tissue: pancreas; tissue type: Normal pancreatic tissue N... controlled vocabulary controlled vocabulary sample type match: normal
sample_type normal tissue sample GSM7071073 Runtime Siftome inference GEO:sample:GSM7071073:0c96cf4276dc459c92784030367f32b915a1e274a5a9d108899b80f9fb3245eb low confidence normal sample_accession: GSM7071073 sample_title: Normal pancreatic tissue 2 [CR562915] source_name: pancreas characteristics: tissue: pancreas; tissue type: Normal pancreatic tissue N... controlled vocabulary controlled vocabulary sample type match: normal
sample_type normal tissue sample GSM7071074 Runtime Siftome inference GEO:sample:GSM7071074:0b4105a1b6d589c1efd170b78634cc25349d195ab92a7b32fca9d8f321f73d59 low confidence normal sample_accession: GSM7071074 sample_title: Normal pancreatic tissue 3 [CR561640] source_name: pancreas characteristics: tissue: pancreas; tissue type: Normal pancreatic tissue N... controlled vocabulary controlled vocabulary sample type match: normal
tissue pancreas dataset GSE226307 Runtime Siftome inference GEO:dataset:GSE226307:213a8b35bca67a5a608fa9d0f94e5678819a23f296e0b18ca8ef8d3d0a4f639d low confidence pancreas dataset_accession: GSE226307 dataset_title: The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Ca... controlled vocabulary controlled vocabulary tissue match: pancreas
tissue pancreas sample GSM7071068 Runtime Siftome inference GEO:sample:GSM7071068:e9461e7d1fe8eb22889ce4e4782b155c5167228b88b439e085a2d881cdc3652f low confidence pancreas sample_accession: GSM7071068 sample_title: Poorly differentiated PDAC 1 [R2971] source_name: pancreas characteristics: tissue: pancreas; tissue type: Poorly differentiated PDAC ... controlled vocabulary controlled vocabulary tissue match: pancreas
tissue pancreas sample GSM7071069 Runtime Siftome inference GEO:sample:GSM7071069:67ac6172a7e734dd7844b3096d0bc3fc557fe0faaa765765fe6f6fc3f91e5d1d low confidence pancreas sample_accession: GSM7071069 sample_title: Poorly differentiated PDAC 2 [R2944] source_name: pancreas characteristics: tissue: pancreas; tissue type: Poorly differentiated PDAC ... controlled vocabulary controlled vocabulary tissue match: pancreas
tissue pancreas sample GSM7071070 Runtime Siftome inference GEO:sample:GSM7071070:147b95da5fca4ab7c108675e89dc6091e0cc142a5089c7dff8f0a075bb212b82 low confidence pancreas sample_accession: GSM7071070 sample_title: Moderately differentiated PDAC 1 [R2824] source_name: pancreas characteristics: tissue: pancreas; tissue type: Moderately differentiat... controlled vocabulary controlled vocabulary tissue match: pancreas
tissue pancreas sample GSM7071071 Runtime Siftome inference GEO:sample:GSM7071071:6028373bf1ea69a76c57e6f0be114b358065449b209e55aaa54bb4770db6c3ff low confidence pancreas sample_accession: GSM7071071 sample_title: Moderately differentiated PDAC 2 [R2700] source_name: pancreas characteristics: tissue: pancreas; tissue type: Moderately differentiat... controlled vocabulary controlled vocabulary tissue match: pancreas
tissue pancreas sample GSM7071072 Runtime Siftome inference GEO:sample:GSM7071072:42b50ad4de630f549fe3688654b9ef086c3520d81b12e83f48deda18334723c9 low confidence pancreas sample_accession: GSM7071072 sample_title: Normal pancreatic tissue 1 [CR560569] source_name: pancreas characteristics: tissue: pancreas; tissue type: Normal pancreatic tissue N... controlled vocabulary controlled vocabulary tissue match: pancreas
tissue pancreas sample GSM7071073 Runtime Siftome inference GEO:sample:GSM7071073:0c96cf4276dc459c92784030367f32b915a1e274a5a9d108899b80f9fb3245eb low confidence pancreas sample_accession: GSM7071073 sample_title: Normal pancreatic tissue 2 [CR562915] source_name: pancreas characteristics: tissue: pancreas; tissue type: Normal pancreatic tissue N... controlled vocabulary controlled vocabulary tissue match: pancreas
tissue pancreas sample GSM7071074 Runtime Siftome inference GEO:sample:GSM7071074:0b4105a1b6d589c1efd170b78634cc25349d195ab92a7b32fca9d8f321f73d59 low confidence pancreas sample_accession: GSM7071074 sample_title: Normal pancreatic tissue 3 [CR561640] source_name: pancreas characteristics: tissue: pancreas; tissue type: Normal pancreatic tissue N... controlled vocabulary controlled vocabulary tissue match: pancreas

Sample Group Preview

Possible case samples

Samples currently treated as the comparison case group.

2
  • GSM7071068 Poorly differentiated PDAC 1 [R2971] pancreatic cancer Case marker detected. pancreas tissue: pancreas; tissue type: Poorly differentiated PDAC
  • GSM7071069 Poorly differentiated PDAC 2 [R2944] pancreatic cancer Case marker detected. pancreas tissue: pancreas; tissue type: Poorly differentiated PDAC

Possible control samples

Samples currently treated as controls or baseline.

3
  • GSM7071072 Normal pancreatic tissue 1 [CR560569] normal tissue Control marker detected. pancreas tissue: pancreas; tissue type: Normal pancreatic tissue
  • GSM7071073 Normal pancreatic tissue 2 [CR562915] normal tissue Control marker detected. pancreas tissue: pancreas; tissue type: Normal pancreatic tissue
  • GSM7071074 Normal pancreatic tissue 3 [CR561640] normal tissue Control marker detected. pancreas tissue: pancreas; tissue type: Normal pancreatic tissue

Unassigned samples

Samples with no explicit case or control marker.

0

No samples

Excluded samples

Samples excluded from grouping by hard exclusion rules.

2
  • GSM7071070 Moderately differentiated PDAC 1 [R2824] excluded: animal sample in human dataset animal sample in human dataset: Animal sample marker detected in a human dataset. pancreas tissue: pancreas; tissue type: Moderately differentiated PDAC
  • GSM7071071 Moderately differentiated PDAC 2 [R2700] excluded: animal sample in human dataset animal sample in human dataset: Animal sample marker detected in a human dataset. pancreas tissue: pancreas; tissue type: Moderately differentiated PDAC

Ambiguous samples

Samples that need manual review before trusting grouping.

0

No samples

Metadata Quality Components

Persisted metadata quality

100 pts
Clarity
100%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata normalized. Tissue clarity: Tissue metadata normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Detected Sample Groups

pancreatic cancer

2 samples
  • GSM7071068 Poorly differentiated PDAC 1 [R2971] pancreas tissue: pancreas; tissue type: Poorly differentiated PDAC
  • GSM7071069 Poorly differentiated PDAC 2 [R2944] pancreas tissue: pancreas; tissue type: Poorly differentiated PDAC

excluded: animal sample in human dataset

2 samples
  • GSM7071070 Moderately differentiated PDAC 1 [R2824] pancreas tissue: pancreas; tissue type: Moderately differentiated PDAC
  • GSM7071071 Moderately differentiated PDAC 2 [R2700] pancreas tissue: pancreas; tissue type: Moderately differentiated PDAC

normal tissue

3 samples
  • GSM7071072 Normal pancreatic tissue 1 [CR560569] pancreas tissue: pancreas; tissue type: Normal pancreatic tissue
  • GSM7071073 Normal pancreatic tissue 2 [CR562915] pancreas tissue: pancreas; tissue type: Normal pancreatic tissue
  • GSM7071074 Normal pancreatic tissue 3 [CR561640] pancreas tissue: pancreas; tissue type: Normal pancreatic tissue

Score Breakdown

100%

relevance

  • Disease or condition metadata normalized.
  • Organism normalized.
  • Assay type normalized.
  • Tissue metadata normalized.
0%

comparison suitability

  • Case and control sample groups detected: pancreatic cancer vs normal tissue.
  • No excluded sample type flags detected.
  • Tumor/normal design boosted for colorectal tumor-vs-normal tissue triage.
  • Patient tissue or biopsy specimens boosted for tissue comparison triage.
  • Non-colorectal gastrointestinal cancer context downgraded for colorectal tissue ranking.
  • Animal sample markers downgraded because this is a human dataset ranking.
100%

metadata quality

  • Sample source clarity: All samples have source metadata and clear GSE/GSM accessions.
  • Group clarity: Rule-based grouping found both case and control samples.
  • Disease clarity: Disease or condition metadata normalized.
  • Tissue clarity: Tissue metadata normalized.
  • Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Replicate clarity: No pooled sample or technical replicate flags detected.
  • Data availability clarity: Dataset-level processed or raw data availability is explicit.
100%

data availability

  • Processed data available.
  • Raw data available.
34%

overall

  • Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because fewer than ten samples limit cohort confidence.
  • Overall score capped because gastrointestinal context is not explicit colorectal/CRC.

Sample Links

7 samples

Review Audit Trail

0 decisions

No review decisions have been stored for this dataset.