Siftome Phase 3L

GSE304666

Transcriptomic profiling of meningiomas reveals SMARCB1 mutation-driven immunosuppression via IL-17/CSF1 axis

Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.
Sample grouping CSV Contrast CSV DESeq2 metadata CSV R handoff notes Handoff report Download instructions Open GEO dataset
Source
GEO
Search intent
Patient tissue tumor-vs-normal
Intent behavior
search-intent-behavior-v1
Submission date
2025-08-06
Last update
2025-10-30
Organization
The Affiliated Shanghai Fourth People's Hospital of Tongji University
Department
Plastic and Reconstructive Surgery
Public date
2025-10-30
Experiment types
Expression profiling by high throughput sequencing
Platforms
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Series type
Series
SubSeries
Not available
BioProject
Not available
Supplementary files
CSV: GSE304666_FPKMs_allSamples.csv.gz
Organism
Homo sapiens
Assay
bulk RNA-seq
Samples
14
Study design
Tumor vs unmatched normal
Specimen/source
Tissue
Scoring version
intent-aware-scoring-v15
Ranking batch
b69568dd1e4fe1b9ee2d880bf5495d748a7e4c5c11e4107f02528c3be0e76012
Ranking created
2026-06-05T20:20:27.088676Z
Warning version
intent-aware-warnings-v2

Current Intent Interpretation

Patient tissue tumor-vs-normal

Expectations

Organism
Homo sapiens
Assay
bulk RNA-seq
Specimen/source
patient tissue or biopsy
Controls
matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control

Rules

Default filters
Human only; Bulk RNA-seq only; Tumor-normal only; Tissue or biopsy only; Hide biofluid/model systems
Warning rules
missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
Score caps
non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
Downgraded contexts
microarray unless explicitly enabled, biofluid-only datasets, cell-line datasets, organoid datasets, xenograft or PDX datasets, non-colorectal disease contexts, or treatment-only experiments

Study Classification

Tumor vs unmatched normal Tissue

Analysis Readiness

Review before analysis
82% DE readiness

Contrast completeness

25/25 pts

Both case and control groups are present in the proposed grouping.

Minimum group size

8/20 pts

A contrast exists, but at least one group is below the minimum sample count.

Processed data availability

20/20 pts

Processed data is marked available in the GEO index.

Sample decision clarity

15/15 pts

All samples are assigned to a case or control group.

Blocking warnings

7/10 pts

Warnings are present, but none are critical blockers.

Metadata normalization

7/10 pts

Metadata quality is usable, but still deserves review.

Blockers

  • At least one contrast group is below the minimum sample count.

Next Steps

  • Review blockers and update sample grouping or dataset selection before analysis.

Analysis Preparation Checklist

4/6 ready

Group labels reviewed

Needs review

Siftome proposed case and control labels, but no reviewer confirmation is stored yet.

Open the sample grouping CSV and confirm group labels before analysis.

Minimum sample count met

Blocked

At least one group has fewer than 2 samples.

Choose a larger dataset or merge only scientifically valid groups.

Processed counts available

Ready

Processed data availability is marked true in the GEO index.

Verify that downloaded processed files contain usable count or expression identifiers.

Ambiguous samples handled

Ready

No review-needed or unassigned samples are present in the proposed grouping.

Still scan the grouping table for biology-specific ambiguity.

Exclusion decisions recorded

Ready

No hard-excluded samples were detected by the current rules.

Record any manual exclusions in the downstream analysis notes.

Source links preserved

Ready

The dataset and sample accessions can be linked back to GEO.

Keep GEO dataset and sample links with exported metadata.

Bioinformatician Review

Bioinformatician review required

Ask a bioinformatician to review grouping, count availability, exclusions, and design before DE.

  • Analysis readiness has blockers that must be resolved before DE.
  • Analysis preparation checklist contains blocked items.
  • At least one comparison group has fewer than two samples.

Why This Is Ranked Here

Patient tissue tumor-vs-normal
Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.

Score Components

  • relevance 50% Organism normalized. Assay type normalized.
  • comparison suitability 5% Tumor and normal sample groups detected. No excluded sample type flags detected. Tumor/normal design boosted for colorectal tumor-vs-normal tissue triage. Patient tissue or biopsy specimens boosted for tissue comparison triage. Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking.
  • metadata quality 70% Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata was not normalized. Tissue clarity: Tissue metadata was not normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.
  • data availability 100% Processed data available. Raw data available.
  • overall 45% Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability. Overall score capped because comparison suitability is weak for the selected search intent. Overall score capped because colorectal/CRC disease context is not explicit.

Derived Classifications

  • Organism Homo sapiens Organism remains rule-derived: Homo sapiens.
  • Assay bulk RNA-seq Assay remains rule-derived: bulk RNA-seq.
  • Study design Tumor vs unmatched normal Study design remains rule-derived: Tumor vs unmatched normal.
  • Specimen/source Tissue Specimen/source remains rule-derived: Tissue.
  • Likely case group tumor sample 13 samples
  • Likely control group normal tissue 1 samples

Warnings

  • DISEASE_LABEL_UNCLEAR warning Disease or condition label could not be normalized.
  • TISSUE_TYPE_MISSING warning Tissue or cell type could not be normalized.

Intent Interpretation

  • Active intent Patient tissue tumor-vs-normal Ranks human colorectal tissue or biopsy cohorts where tumor samples can be compared with normal controls.
  • Organism expectation Homo sapiens Dataset organism is interpreted as Homo sapiens.
  • Assay expectation bulk RNA-seq Dataset assay is interpreted as bulk RNA-seq.
  • Specimen assumption patient tissue or biopsy Derived specimen/source is Tissue.
  • Control-group assumption matched normal, adjacent normal, paired normal, healthy tissue control, or otherwise normal tissue control Derived study design is Tumor vs unmatched normal; likely groups are tumor sample vs normal tissue.
  • Score caps Applied when matching conditions are present non-human datasets stay below the primary recommendation band, missing colorectal/colon/rectal/CRC context stays below the primary recommendation band, biofluid and model-system datasets cannot reach Recommended by default, microarray and secondary assays are capped unless explicitly enabled, or small cohorts are capped below high-confidence recommendations
  • Warning rules 2 active warnings missing or unclear control group, unclear disease context, unclear tissue source, mixed sample types, model-system markers, secondary assay context, missing processed data, or small cohort size
  • Downgrade or exclusion reason Downgraded disease context: colorectal/GI relevance is unclear. Derived from current-intent ranking reasons and warnings.

Applied Review Decisions

No active review decisions affect this ranking.

Ranking Facts

  • Recommendation Exploratory only Dataset can inform exploration but is not strong enough for primary analysis.
  • Supporting fact Tumor vs unmatched normal · Tissue · suitability 5%. Contributed to match or upgrade evidence.
  • Supporting fact Prioritized assay: bulk RNA-seq is the active assay expectation. Contributed to match or upgrade evidence.
  • Supporting fact Downgraded disease context: colorectal/GI relevance is unclear. Contributed to match or upgrade evidence.
  • Supporting fact Processed data is available for downstream review. Contributed to match or upgrade evidence.
  • Supporting fact 2 warnings require review. Contributed to match or upgrade evidence.
  • Caution fact Disease or condition label could not be normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Tissue or cell type could not be normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Disease clarity: Disease or condition metadata was not normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Tissue clarity: Tissue metadata was not normalized. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because comparison suitability is weak for the selected search intent. Contributed to downgrade or manual-review evidence.
  • Caution fact Overall score capped because colorectal/CRC disease context is not explicit. Contributed to downgrade or manual-review evidence.
  • Caution fact Downgraded disease context: colorectal/GI relevance is unclear. Contributed to downgrade or manual-review evidence.
  • Caution fact Missing or unclear metadata: Downgraded disease context: colorectal/GI relevance is unclear. Contributed to downgrade or manual-review evidence.
  • Caution fact Comparison suitability score is below the Phase 1 recommended threshold. Contributed to downgrade or manual-review evidence.

Manual Corrections

0 active

Source Evidence

4 sources

GEO

Primary source

Original dataset metadata, sample metadata, source links, and GEO data availability flags.

Dataset accession
GSE304666
Sample records
14 GSM samples
  • GEO has priority for original metadata under the Phase 3J source rules.
  • Processed data: available.
  • Raw data: available.
  • No external source conflict is present in the current runtime data.

recount3

Not imported

Planned trusted source for processed count availability.

GEO accession
GSE304666
  • No recount3 project identifier has been imported for this dataset.
  • Once imported, recount3 has priority for processed count availability.
  • The recount3 source filter excludes this dataset until that linkage exists.
No recount3 sync data available.

Expression Atlas

Not imported

Planned source for curated expression experiment links.

GEO accession
GSE304666
  • No Expression Atlas experiment identifier has been imported for this dataset.
  • Once imported, Expression Atlas has priority for curated expression experiment links.
  • The Expression Atlas source filter excludes this dataset until that linkage exists.
No Expression Atlas sync data available.

PubMed

Unavailable

Publication context when PubMed identifiers are already known.

GEO accession
GSE304666
  • No PubMed identifier is present in the current runtime metadata.
  • No live PubMed search is performed from the dataset detail page.
No publication identifier imported.

Dataset Feedback

0 stored

Original GEO Metadata

dataset_accession: GSE304666
dataset_title: Transcriptomic profiling of meningiomas reveals SMARCB1 mutation-driven immunosuppression via IL-17/CSF1 axis
organism: Homo sapiens
assay_type: bulk RNA-seq
processed_data_available: true
raw_data_available: true
submission_date: 2025-08-06
last_update_date: 2025-10-30
organization_name: The Affiliated Shanghai Fourth People's Hospital of Tongji University
department: Plastic and Reconstructive Surgery
public_date: 2025-10-30
experiment_types: Expression profiling by high throughput sequencing
platforms: GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
sub_series: Not available
bioproject: Not available
supplementary_files: CSV: GSE304666_FPKMs_allSamples.csv.gz
series_type: Series

Why It Matched

  • Tumor vs unmatched normal · Tissue · suitability 5%.
  • Prioritized assay: bulk RNA-seq is the active assay expectation.
  • Downgraded disease context: colorectal/GI relevance is unclear.
  • Processed data is available for downstream review.
  • 2 warnings require review.

Why It May Not Be Suitable

  • Disease or condition label could not be normalized.
  • Tissue or cell type could not be normalized.
  • Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking.
  • Missing or unclear metadata: Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking.
  • Missing or unclear metadata: Disease clarity: Disease or condition metadata was not normalized.
  • Missing or unclear metadata: Tissue clarity: Tissue metadata was not normalized.
  • Missing or unclear metadata: Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because colorectal/CRC disease context is not explicit.
  • Downgraded disease context: colorectal/GI relevance is unclear.
  • Missing or unclear metadata: Downgraded disease context: colorectal/GI relevance is unclear.
  • Comparison suitability score is below the Phase 1 recommended threshold.

Warnings

  • warning DISEASE_LABEL_UNCLEAR Disease or condition label could not be normalized.
  • warning TISSUE_TYPE_MISSING Tissue or cell type could not be normalized.

Normalized Fields

16 fields
Field Value Source Origin Confidence Evidence Reason
assay_type bulk RNA-seq dataset GSE304666 Runtime Siftome inference GEO:dataset:GSE304666:ed257a8c84299d22c0b465b15a7e759c9b08738f10686f1c19c1ca307acce998 high confidence bulk rna-seq dataset_accession: GSE304666 dataset_title: Transcriptomic profiling of meningiomas reveals SMARCB1 mutation-driven immunosuppression via IL-17/CSF1 axis organism: Homo sapiens ... keyword match keyword match: bulk rna-seq
organism Homo sapiens dataset GSE304666 Runtime Siftome inference GEO:dataset:GSE304666:ed257a8c84299d22c0b465b15a7e759c9b08738f10686f1c19c1ca307acce998 high confidence homo sapiens dataset_accession: GSE304666 dataset_title: Transcriptomic profiling of meningiomas reveals SMARCB1 mutation-driven immunosuppression via IL-17/CSF1 axis organism: Homo sapiens ... keyword match keyword match: homo sapiens
sample_type tumor sample sample GSM9154972 Runtime Siftome inference GEO:sample:GSM9154972:b6577c4bf8b296c899e7f2f2a597ba619c9ef7e64d84014773e845b7119ff249 low confidence tumor sample_accession: GSM9154972 sample_title: RNA-seq of primary WHO G1 meningioma 1 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq of ... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154973 Runtime Siftome inference GEO:sample:GSM9154973:6e78fac8dceacdcb0ccd621f0ad5ac80fad7bab2cd06ad4bc91fb5164bb51d1c low confidence tumor sample_accession: GSM9154973 sample_title: RNA-seq of primary WHO G1 meningioma 2 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq of ... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154974 Runtime Siftome inference GEO:sample:GSM9154974:4873e2444a68ae350ad4b903a6f63efc7c2a9f7e13436635eaf6d3f46abc0308 low confidence tumor sample_accession: GSM9154974 sample_title: RNA-seq of primary WHO G1 meningioma 3 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq of ... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154975 Runtime Siftome inference GEO:sample:GSM9154975:fe7261ba35bd43cfc9bb83e8b37696a319a8d1bd600b211e7d7415cfbb9c91b0 low confidence tumor sample_accession: GSM9154975 sample_title: RNA-seq of recurrent WHO G1 meningioma 1 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq o... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154976 Runtime Siftome inference GEO:sample:GSM9154976:28b8ab740051e4103276981e1844b0c42013d2b399dc36d37188db3a7f8f0773 low confidence tumor sample_accession: GSM9154976 sample_title: RNA-seq of recurrent WHO G1 meningioma 2 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq o... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154977 Runtime Siftome inference GEO:sample:GSM9154977:6bb0da4704eaa1d1535b3287c94daece8951f07d98472b87d2a0dfeaef4c86d2 low confidence tumor sample_accession: GSM9154977 sample_title: RNA-seq of primary WHO G2 meningioma 1 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq of ... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154978 Runtime Siftome inference GEO:sample:GSM9154978:a1e15c87e986446f1666c48e9bc91b739a2f861a6089a5081518b510d9a3a074 low confidence tumor sample_accession: GSM9154978 sample_title: RNA-seq of primary WHO G2 meningioma 2 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq of ... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154979 Runtime Siftome inference GEO:sample:GSM9154979:593b41d034f649272ed02fd56964f238a05c9b37436e5346b601b37acccf1112 low confidence tumor sample_accession: GSM9154979 sample_title: RNA-seq of primary WHO G2 meningioma 3 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq of ... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154980 Runtime Siftome inference GEO:sample:GSM9154980:6265a9749c2866670ada27b58d7879c6da266bb34c5611459b0966c79e77d62f low confidence tumor sample_accession: GSM9154980 sample_title: RNA-seq of recurrent WHO G2 meningioma 1 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq o... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154981 Runtime Siftome inference GEO:sample:GSM9154981:482fb6b3fdc07381102007986bf36b8dc36d3a42dd0c47f30e701479411ee642 low confidence tumor sample_accession: GSM9154981 sample_title: RNA-seq of recurrent WHO G2 meningioma 2 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq o... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154982 Runtime Siftome inference GEO:sample:GSM9154982:30c5422a5d4aa12822b8b8a07dcdf6eab86c50ea062139692ab3ee7fb6cc3683 low confidence tumor sample_accession: GSM9154982 sample_title: RNA-seq of primary WHO G3 meningioma 1 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq of ... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154983 Runtime Siftome inference GEO:sample:GSM9154983:bf484694e1a7cd7a470500765562936973667d5e90194e719af0789f1dffde12 low confidence tumor sample_accession: GSM9154983 sample_title: RNA-seq of primary WHO G3 meningioma 2 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq of ... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type tumor sample sample GSM9154984 Runtime Siftome inference GEO:sample:GSM9154984:e8e42c4ce8c4cf0c848d8f9f233f01e8be53a409ebfeecf7427bdcad1be74e37 low confidence tumor sample_accession: GSM9154984 sample_title: RNA-seq of primary WHO G3 meningioma 3 source_name: Meningioma characteristics: tissue: Meningioma; cell type: tumor cells RNA-seq of ... controlled vocabulary controlled vocabulary sample type match: tumor
sample_type normal tissue sample GSM9154985 Runtime Siftome inference GEO:sample:GSM9154985:55fc41a50af5abcb80f1ec7fe245de2aaf5b886bb14ab9dc3640ffdf95dedf59 low confidence normal sample_accession: GSM9154985 sample_title: RNA-seq of meningioma control dura 1 source_name: Dura mater characteristics: tissue: Dura mater; cell type: normal cells RNA-seq of m... controlled vocabulary controlled vocabulary sample type match: normal

Sample Group Preview

Possible case samples

Samples currently treated as the comparison case group.

13
  • GSM9154972 RNA-seq of primary WHO G1 meningioma 1 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154973 RNA-seq of primary WHO G1 meningioma 2 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154974 RNA-seq of primary WHO G1 meningioma 3 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154975 RNA-seq of recurrent WHO G1 meningioma 1 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154976 RNA-seq of recurrent WHO G1 meningioma 2 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154977 RNA-seq of primary WHO G2 meningioma 1 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154978 RNA-seq of primary WHO G2 meningioma 2 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154979 RNA-seq of primary WHO G2 meningioma 3 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154980 RNA-seq of recurrent WHO G2 meningioma 1 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154981 RNA-seq of recurrent WHO G2 meningioma 2 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154982 RNA-seq of primary WHO G3 meningioma 1 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154983 RNA-seq of primary WHO G3 meningioma 2 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154984 RNA-seq of primary WHO G3 meningioma 3 tumor sample Case marker detected. Meningioma tissue: Meningioma; cell type: tumor cells

Possible control samples

Samples currently treated as controls or baseline.

1
  • GSM9154985 RNA-seq of meningioma control dura 1 normal tissue Control marker detected. Dura mater tissue: Dura mater; cell type: normal cells

Unassigned samples

Samples with no explicit case or control marker.

0

No samples

Excluded samples

Samples excluded from grouping by hard exclusion rules.

0

No samples

Ambiguous samples

Samples that need manual review before trusting grouping.

0

No samples

Metadata Quality Components

Persisted metadata quality

70 pts
Clarity
70%
Weight
100 pts

Sample source clarity: All samples have source metadata and clear GSE/GSM accessions. Group clarity: Rule-based grouping found both case and control samples. Disease clarity: Disease or condition metadata was not normalized. Tissue clarity: Tissue metadata was not normalized. Treatment clarity: No unclear treatment split detected in the sample metadata. Replicate clarity: No pooled sample or technical replicate flags detected. Data availability clarity: Dataset-level processed or raw data availability is explicit.

Detected Sample Groups

tumor sample

13 samples
  • GSM9154972 RNA-seq of primary WHO G1 meningioma 1 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154973 RNA-seq of primary WHO G1 meningioma 2 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154974 RNA-seq of primary WHO G1 meningioma 3 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154975 RNA-seq of recurrent WHO G1 meningioma 1 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154976 RNA-seq of recurrent WHO G1 meningioma 2 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154977 RNA-seq of primary WHO G2 meningioma 1 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154978 RNA-seq of primary WHO G2 meningioma 2 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154979 RNA-seq of primary WHO G2 meningioma 3 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154980 RNA-seq of recurrent WHO G2 meningioma 1 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154981 RNA-seq of recurrent WHO G2 meningioma 2 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154982 RNA-seq of primary WHO G3 meningioma 1 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154983 RNA-seq of primary WHO G3 meningioma 2 Meningioma tissue: Meningioma; cell type: tumor cells
  • GSM9154984 RNA-seq of primary WHO G3 meningioma 3 Meningioma tissue: Meningioma; cell type: tumor cells

normal tissue

1 sample
  • GSM9154985 RNA-seq of meningioma control dura 1 Dura mater tissue: Dura mater; cell type: normal cells

Score Breakdown

50%

relevance

  • Organism normalized.
  • Assay type normalized.
5%

comparison suitability

  • Tumor and normal sample groups detected.
  • No excluded sample type flags detected.
  • Tumor/normal design boosted for colorectal tumor-vs-normal tissue triage.
  • Patient tissue or biopsy specimens boosted for tissue comparison triage.
  • Missing colorectal disease context downgraded for tumor-vs-normal tissue ranking.
70%

metadata quality

  • Sample source clarity: All samples have source metadata and clear GSE/GSM accessions.
  • Group clarity: Rule-based grouping found both case and control samples.
  • Disease clarity: Disease or condition metadata was not normalized.
  • Tissue clarity: Tissue metadata was not normalized.
  • Treatment clarity: No unclear treatment split detected in the sample metadata.
  • Replicate clarity: No pooled sample or technical replicate flags detected.
  • Data availability clarity: Dataset-level processed or raw data availability is explicit.
100%

data availability

  • Processed data available.
  • Raw data available.
45%

overall

  • Weighted score: 30% relevance, 30% comparison suitability, 25% metadata quality, 15% data availability.
  • Overall score capped because comparison suitability is weak for the selected search intent.
  • Overall score capped because colorectal/CRC disease context is not explicit.

Sample Links

14 samples

Review Audit Trail

0 decisions

No review decisions have been stored for this dataset.